TY - JOUR
T1 - Severe Coronavirus disease (COVID)-19
T2 - from pathogenesis to therapy
AU - Cavaillon, Jean-Marc
AU - Artigas, Antonio
AU - Barratt-Due, Andreas
AU - Giamarellos-Bourboulis, Evangelos J.
AU - Gómez, Hernando
AU - Hayem, Gilles
AU - Vlaar, Alexander P. J.
AU - Wiersinga, W. Joost
N1 - Publisher Copyright: © Wolters Kluwer Health, Inc. All rights reserved.
PY - 2023/3/1
Y1 - 2023/3/1
N2 - The COVID-19 pandemic has been a challenge to propose efficient therapies. Because severe SARS-CoV2 infection is a viral sepsis eventually followed by an immunological autoinflammatory phenomenon, many approaches have been inspired by the previous attempts made in bacterial sepsis, while specific antiviral strategies (use of interferon or specific drugs) have been additionally investigated. We summarize our current thinking on the use of SARS-CoV-2 antivirals, corticosteroids, anti-IL-1, anti-IL-6, anti-C5a, as well as stem cell therapy in severe COVID-19. Patient stratification and appropriate time window will be important to be defined to guide successful treatment.
AB - The COVID-19 pandemic has been a challenge to propose efficient therapies. Because severe SARS-CoV2 infection is a viral sepsis eventually followed by an immunological autoinflammatory phenomenon, many approaches have been inspired by the previous attempts made in bacterial sepsis, while specific antiviral strategies (use of interferon or specific drugs) have been additionally investigated. We summarize our current thinking on the use of SARS-CoV-2 antivirals, corticosteroids, anti-IL-1, anti-IL-6, anti-C5a, as well as stem cell therapy in severe COVID-19. Patient stratification and appropriate time window will be important to be defined to guide successful treatment.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85149977686&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/36469709
U2 - https://doi.org/10.1097/SHK.0000000000001956
DO - https://doi.org/10.1097/SHK.0000000000001956
M3 - Article
C2 - 36469709
SN - 1073-2322
VL - 59
SP - 10
EP - 15
JO - Shock (Augusta, Ga.)
JF - Shock (Augusta, Ga.)
IS - 3
ER -