TY - JOUR
T1 - Definitions of Urinary Tract Infection in Current Research
T2 - A Systematic Review
AU - Bilsen, Manu P.
AU - Jongeneel, Rosa M. H.
AU - Schneeberger, Caroline
AU - Platteel, Tamara N.
AU - van Nieuwkoop, Cees
AU - Mody, Lona
AU - Caterino, Jeffrey M.
AU - Geerlings, Suzanne E.
AU - Köves, Bela
AU - Wagenlehner, Florian
AU - Conroy, Simon P.
AU - Visser, Leo G.
AU - Lambregts, Merel M. C.
N1 - Publisher Copyright: © 2023 The Author(s). Published by Oxford University Press on behalf of Infectious Diseases Society of America.
PY - 2023/7/1
Y1 - 2023/7/1
N2 - Defining urinary tract infection (UTI) is complex, as numerous clinical and diagnostic parameters are involved. In this systematic review, we aimed to gain insight into how UTI is defined across current studies. We included 47 studies, published between January 2019 and May 2022, investigating therapeutic or prophylactic interventions in adult patients with UTI. Signs and symptoms, pyuria, and a positive urine culture were required in 85%, 28%, and 55% of study definitions, respectively. Five studies (11%) required all 3 categories for the diagnosis of UTI. Thresholds for significant bacteriuria varied from 103 to 105 colony-forming units/mL. None of the 12 studies including acute cystitis and 2 of 12 (17%) defining acute pyelonephritis used identical definitions. Complicated UTI was defined by both host factors and systemic involvement in 9 of 14 (64%) studies. In conclusion, UTI definitions are heterogeneous across recent studies, highlighting the need for a consensus-based, research reference standard for UTI.
AB - Defining urinary tract infection (UTI) is complex, as numerous clinical and diagnostic parameters are involved. In this systematic review, we aimed to gain insight into how UTI is defined across current studies. We included 47 studies, published between January 2019 and May 2022, investigating therapeutic or prophylactic interventions in adult patients with UTI. Signs and symptoms, pyuria, and a positive urine culture were required in 85%, 28%, and 55% of study definitions, respectively. Five studies (11%) required all 3 categories for the diagnosis of UTI. Thresholds for significant bacteriuria varied from 103 to 105 colony-forming units/mL. None of the 12 studies including acute cystitis and 2 of 12 (17%) defining acute pyelonephritis used identical definitions. Complicated UTI was defined by both host factors and systemic involvement in 9 of 14 (64%) studies. In conclusion, UTI definitions are heterogeneous across recent studies, highlighting the need for a consensus-based, research reference standard for UTI.
KW - complicated urinary tract infection
KW - cystitis
KW - definition
KW - pyelonephritis
KW - urinary tract infection
UR - http://www.scopus.com/inward/record.url?scp=85165405550&partnerID=8YFLogxK
U2 - https://doi.org/10.1093/ofid/ofad332
DO - https://doi.org/10.1093/ofid/ofad332
M3 - Review article
C2 - 37426954
SN - 2328-8957
VL - 10
JO - Open forum infectious diseases
JF - Open forum infectious diseases
IS - 7
M1 - ofad332
ER -