TY - JOUR
T1 - Assessment of left atrial electro-mechanical delay to predict atrial fibrillation in hypertrophic cardiomyopathy
AU - Tjahjadi, Catherina
AU - Hiemstra, Yasmine L.
AU - van der Bijl, Pieter
AU - Pio, Stephan M.
AU - Bootsma, Marianne
AU - Ajmone Marsan, Nina
AU - Delgado, Victoria
AU - Bax, Jeroen J.
N1 - Publisher Copyright: © 2020 Published on behalf of the European Society of Cardiology.
PY - 2021/5/1
Y1 - 2021/5/1
N2 - AIMS: Atrial fibrillation (AF) is frequently observed in hypertrophic cardiomyopathy (HCM) and is associated with poor clinical outcome. Total atrial conduction time, estimated by tissue Doppler imaging (TDI), the so-called PA-TDI duration, reflects the left atrial (LA) structural and electrical remodelling. The aim of this study was to evaluate the association between PA-TDI and new-onset AF in patients with HCM. METHODS AND RESULTS: From a large cohort of patients with HCM, 208 patients (64% male, mean age 53 ± 14 years) without AF were selected. PA-TDI duration was measured from the onset P wave on electrocardiogram to the peak A' wave of the lateral LA wall using TDI. The incidence of new-onset AF was 20% over a median follow-up of 7.3 (3.5-10.5) years. Patients with incident AF had longer PA-TDI duration when compared with patients without AF (133.7 ± 23.0 vs. 110.5 ± 30.0 ms, P < 0.001). PA-TDI duration was independently associated with new-onset AF (hazard ratio: 1.03, 95% confidence interval: 1.01-1.05, P < 0.001). CONCLUSION: Prolonged PA-TDI duration was independently associated with new-onset AF in patients with HCM. This novel parameter could be useful to risk-stratify patients with HCM who are at risk of having AF.
AB - AIMS: Atrial fibrillation (AF) is frequently observed in hypertrophic cardiomyopathy (HCM) and is associated with poor clinical outcome. Total atrial conduction time, estimated by tissue Doppler imaging (TDI), the so-called PA-TDI duration, reflects the left atrial (LA) structural and electrical remodelling. The aim of this study was to evaluate the association between PA-TDI and new-onset AF in patients with HCM. METHODS AND RESULTS: From a large cohort of patients with HCM, 208 patients (64% male, mean age 53 ± 14 years) without AF were selected. PA-TDI duration was measured from the onset P wave on electrocardiogram to the peak A' wave of the lateral LA wall using TDI. The incidence of new-onset AF was 20% over a median follow-up of 7.3 (3.5-10.5) years. Patients with incident AF had longer PA-TDI duration when compared with patients without AF (133.7 ± 23.0 vs. 110.5 ± 30.0 ms, P < 0.001). PA-TDI duration was independently associated with new-onset AF (hazard ratio: 1.03, 95% confidence interval: 1.01-1.05, P < 0.001). CONCLUSION: Prolonged PA-TDI duration was independently associated with new-onset AF in patients with HCM. This novel parameter could be useful to risk-stratify patients with HCM who are at risk of having AF.
KW - atrial fibrillation
KW - hypertrophic cardiomyopathy
KW - total atrial conduction time
UR - http://www.scopus.com/inward/record.url?scp=85105833875&partnerID=8YFLogxK
U2 - https://doi.org/10.1093/ehjci/jeaa174
DO - https://doi.org/10.1093/ehjci/jeaa174
M3 - Article
C2 - 32588037
SN - 2047-2404
VL - 22
SP - 589
EP - 596
JO - European heart journal cardiovascular Imaging
JF - European heart journal cardiovascular Imaging
IS - 5
ER -