TY - JOUR
T1 - Joint EANM/SNMMI/IHPBA procedure guideline for [99mTc]Tc-mebrofenin hepatobiliary scintigraphy SPECT/CT in the quantitative assessment of the future liver remnant function
AU - Arntz, Pieter J. W.
AU - Deroose, Christophe M.
AU - Marcus, Charles
AU - Sturesson, Christian
AU - Panaro, Fabrizio
AU - Erdmann, Joris
AU - Manevska, Nevena
AU - Moadel, Renee
AU - de Geus-Oei, Lioe-Fee
AU - Bennink, Roel J.
N1 - Funding Information: This guideline was brought to the attention of the EANM Oncology and Theranostics Committee. The comments and suggestions from the SNMMI, IHPBA, EANM Technologists, Physics- and Oncology and Theranostics Committee, and the National Societies of Nuclear Medicine were highly appreciated and have been included in this guideline. Figures created with BioRender.com. Publisher Copyright: © 2023 The Authors
PY - 2023/10/1
Y1 - 2023/10/1
N2 - Purpose: The aim of this joint EANM/SNMMI/IHPBA procedure guideline is to provide general information and specific recommendations and considerations on the use of [99mTc]Tc-mebrofenin hepatobiliary scintigraphy (HBS) in the quantitative assessment and risk analysis before surgical intervention, selective internal radiation therapy (SIRT) or before and after liver regenerative procedures. Although the gold standard to estimate future liver remnant (FLR) function remains volumetry, the increasing interest in HBS and the continuous request for implementation in major liver centers worldwide, demands standardization. Methods: This guideline concentrates on the endorsement of a standardized protocol for HBS elaborates on the clinical indications and implications, considerations, clinical appliance, cut-off values, interactions, acquisition, post-processing analysis and interpretation. Referral to the practical guidelines for additional post-processing manual instructions is provided. Conclusion: The increasing interest of major liver centers worldwide in HBS requires guidance for implementation. Standardization facilitates applicability of HBS and promotes global implementation. Inclusion of HBS in standard care is not meant as substitute for volumetry, but rather to complement risk evaluation by identifying suspected and unsuspected high-risk patients prone to develop post-hepatectomy liver failure (PHLF) and post-SIRT liver failure.
AB - Purpose: The aim of this joint EANM/SNMMI/IHPBA procedure guideline is to provide general information and specific recommendations and considerations on the use of [99mTc]Tc-mebrofenin hepatobiliary scintigraphy (HBS) in the quantitative assessment and risk analysis before surgical intervention, selective internal radiation therapy (SIRT) or before and after liver regenerative procedures. Although the gold standard to estimate future liver remnant (FLR) function remains volumetry, the increasing interest in HBS and the continuous request for implementation in major liver centers worldwide, demands standardization. Methods: This guideline concentrates on the endorsement of a standardized protocol for HBS elaborates on the clinical indications and implications, considerations, clinical appliance, cut-off values, interactions, acquisition, post-processing analysis and interpretation. Referral to the practical guidelines for additional post-processing manual instructions is provided. Conclusion: The increasing interest of major liver centers worldwide in HBS requires guidance for implementation. Standardization facilitates applicability of HBS and promotes global implementation. Inclusion of HBS in standard care is not meant as substitute for volumetry, but rather to complement risk evaluation by identifying suspected and unsuspected high-risk patients prone to develop post-hepatectomy liver failure (PHLF) and post-SIRT liver failure.
UR - http://www.scopus.com/inward/record.url?scp=85163485608&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.hpb.2023.06.001
DO - https://doi.org/10.1016/j.hpb.2023.06.001
M3 - Article
C2 - 37394397
SN - 1365-182X
VL - 25
SP - 1131
EP - 1144
JO - HPB
JF - HPB
IS - 10
ER -