TY - JOUR
T1 - Early-life exposures and cardiovascular disease risk among Ghanaian migrant and home populations: The RODAM study
AU - Boateng, Daniel
AU - Danquah, Ina
AU - Said-Mohamed, Rihlat
AU - Smeeth, Liam
AU - Nicolaou, Mary
AU - Meeks, Karlijn
AU - Beune, Erik
AU - Addo, Juliet
AU - Bahendeka, Silver
AU - Agyei-Baffour, Peter
AU - Mockenhaupt, Frank P.
AU - Spranger, Joachim
AU - Schulze, Matthias B.
AU - Grobbee, Diederick E.
AU - Agyemang, Charles
AU - Klipstein-Grobusch, Kerstin
PY - 2020/6/1
Y1 - 2020/6/1
N2 - Early-life environmental and nutritional exposures are considered to contribute to the differences in cardiovascular disease (CVD) burden. Among sub-Saharan African populations, the association between markers of early-life exposures such as leg length and sitting height and CVD risk is yet to be investigated. This study assessed the association between leg length, sitting height, and estimated 10-year atherosclerotic cardiovascular disease (ASCVD) risk among Ghanaian-born populations in Europe and Ghana. We constructed sex-specific quintiles for sitting height and leg length for 3250 participants aged 40-70 years (mean age 52 years; men 39.6%; women 60.4%) in the cross-sectional multicenter Research on Diabetes and Obesity among African Migrants study. Ten-year risk of ASCVD was estimated using the Pooled Cohort Equations; risk ≥7.5% was defined as "elevated" CVD risk. Prevalence ratios (PR) were estimated to determine the associations between sitting height, leg length, and estimated 10-year ASCVD risk. For both men and women, mean sitting height and leg length were highest in Europe and lowest in rural Ghana. Sitting height was inversely associated with 10-year ASCVD risk among all women (PR for 1 standard deviation increase of sitting height: 0.75; 95% confidence interval: 0.67, 0.85). Among men, an inverse association between sitting height and 10-year ASCVD risk was significant on adjustment for study site, adult, and parental education but attenuated when further adjusted for height. No association was found between leg length and estimated 10-year ASCVD risk. Early-life and childhood exposures that influence sitting height could be the important determinants of ASCVD risk in this adult population.
AB - Early-life environmental and nutritional exposures are considered to contribute to the differences in cardiovascular disease (CVD) burden. Among sub-Saharan African populations, the association between markers of early-life exposures such as leg length and sitting height and CVD risk is yet to be investigated. This study assessed the association between leg length, sitting height, and estimated 10-year atherosclerotic cardiovascular disease (ASCVD) risk among Ghanaian-born populations in Europe and Ghana. We constructed sex-specific quintiles for sitting height and leg length for 3250 participants aged 40-70 years (mean age 52 years; men 39.6%; women 60.4%) in the cross-sectional multicenter Research on Diabetes and Obesity among African Migrants study. Ten-year risk of ASCVD was estimated using the Pooled Cohort Equations; risk ≥7.5% was defined as "elevated" CVD risk. Prevalence ratios (PR) were estimated to determine the associations between sitting height, leg length, and estimated 10-year ASCVD risk. For both men and women, mean sitting height and leg length were highest in Europe and lowest in rural Ghana. Sitting height was inversely associated with 10-year ASCVD risk among all women (PR for 1 standard deviation increase of sitting height: 0.75; 95% confidence interval: 0.67, 0.85). Among men, an inverse association between sitting height and 10-year ASCVD risk was significant on adjustment for study site, adult, and parental education but attenuated when further adjusted for height. No association was found between leg length and estimated 10-year ASCVD risk. Early-life and childhood exposures that influence sitting height could be the important determinants of ASCVD risk in this adult population.
KW - Ghanaians
KW - Leg length
KW - Pooled Cohort Equation
KW - cardiovascular disease risk
KW - sitting height
UR - http://www.scopus.com/inward/record.url?scp=85072846057&partnerID=8YFLogxK
U2 - https://doi.org/10.1017/S2040174419000527
DO - https://doi.org/10.1017/S2040174419000527
M3 - Article
C2 - 31556361
SN - 2040-1744
VL - 11
SP - 250
EP - 263
JO - Journal of developmental origins of health and disease
JF - Journal of developmental origins of health and disease
IS - 3
ER -