TY - JOUR
T1 - Early-life factors are associated with waist circumference and type 2 diabetes among Ghanaian adults: The RODAM Study
AU - Danquah, Ina
AU - Addo, Juliet
AU - Boateng, Daniel
AU - Klipstein-Grobusch, Kerstin
AU - Meeks, Karlijn
AU - Galbete, Cecilia
AU - Beune, Erik
AU - Bahendeka, Silver
AU - Spranger, Joachim
AU - Mockenhaupt, Frank P.
AU - Stronks, Karien
AU - Agyemang, Charles
AU - Schulze, Matthias B.
AU - Smeeth, Liam
PY - 2019
Y1 - 2019
N2 - Early-life experiences may fuel the emergence of obesity and type 2 diabetes among African populations. We evaluated childhood socio-economic status (SES) and childhood nutritional status as risk factors for increased waist circumference and type 2 diabetes among Ghanaian adults. In the multi-center, cross-sectional Research on Obesity and Diabetes among African Migrants (RODAM) Study, we calculated associations (adjusted for demographics and lifestyle) of parental education and anthropometric markers of childhood nutrition [leg length, leg length-to-height ratio (LHR)] with waist circumference and type 2 diabetes, respectively. Among 5,575 participants (mean age: 46.2 years; 62% female), lower education of either parent (vs. higher) was consistently associated with higher waist circumference (∆: 1.6–3.4 cm). Lower father’s education tended to increase the odds of type 2 diabetes by 50% in women (95% confidence interval (CI): 1.0, 2.4). Reduced leg length and LHR were associated with higher waist circumference. But only in men, leg length was inversely related to type 2 diabetes (OR per 1 standard deviation decrease: 1.1; 95% CI: 1.0, 1.3). In this study, markers of poor childhood SES and early-life nutritional status relate to abdominal obesity in men and women and to type 2 diabetes in men. Thus, prevention efforts should start in early childhood.
AB - Early-life experiences may fuel the emergence of obesity and type 2 diabetes among African populations. We evaluated childhood socio-economic status (SES) and childhood nutritional status as risk factors for increased waist circumference and type 2 diabetes among Ghanaian adults. In the multi-center, cross-sectional Research on Obesity and Diabetes among African Migrants (RODAM) Study, we calculated associations (adjusted for demographics and lifestyle) of parental education and anthropometric markers of childhood nutrition [leg length, leg length-to-height ratio (LHR)] with waist circumference and type 2 diabetes, respectively. Among 5,575 participants (mean age: 46.2 years; 62% female), lower education of either parent (vs. higher) was consistently associated with higher waist circumference (∆: 1.6–3.4 cm). Lower father’s education tended to increase the odds of type 2 diabetes by 50% in women (95% confidence interval (CI): 1.0, 2.4). Reduced leg length and LHR were associated with higher waist circumference. But only in men, leg length was inversely related to type 2 diabetes (OR per 1 standard deviation decrease: 1.1; 95% CI: 1.0, 1.3). In this study, markers of poor childhood SES and early-life nutritional status relate to abdominal obesity in men and women and to type 2 diabetes in men. Thus, prevention efforts should start in early childhood.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85069663646&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/31350427
U2 - https://doi.org/10.1038/s41598-019-47169-6
DO - https://doi.org/10.1038/s41598-019-47169-6
M3 - Article
C2 - 31350427
SN - 2045-2322
VL - 9
JO - Scientific reports
JF - Scientific reports
IS - 1
M1 - 10848
ER -