TY - JOUR
T1 - Early myocardial deformation abnormalities in breast cancer survivors
AU - Bulten, Ben F.
AU - Mavinkurve-Groothuis, Annelies M. C.
AU - de Geus-Oei, Lioe-Fee
AU - de Haan, Anton F. J.
AU - de Korte, Chris L.
AU - Bellersen, Louise
AU - van Laarhoven, Hanneke W. M.
AU - Kapusta, Livia
PY - 2014
Y1 - 2014
N2 - To evaluate the role of 2D myocardial strain (rate) imaging in the detection of early subclinical cardiotoxicity in breast cancer survivors treated with an anthracycline-based chemotherapeutic regimen. 57 adult breast cancer survivors were analyzed 1 year after therapy. All patients underwent biomarker analysis and 2D echocardiography consisting of conventional echocardiographic and strain (rate) parameters. Conventional echocardiographic values were normal. Global longitudinal strain was normal, but 18 % of patients showed a > 2 SD decrease when individually compared to reference values. This subgroup showed a decrease in end-systolic and end-diastolic volumes and an increase in left ventricular mass. Radial and circumferential strain rates were significantly decreased in the whole study group. 2D myocardial strain (rate) imaging showed abnormalities in breast cancer survivors, while conventional echocardiographic values remained normal, rendering 2D myocardial strain (rate) imaging an interesting tool for the early detection of anthracycline-induced cardiotoxicity
AB - To evaluate the role of 2D myocardial strain (rate) imaging in the detection of early subclinical cardiotoxicity in breast cancer survivors treated with an anthracycline-based chemotherapeutic regimen. 57 adult breast cancer survivors were analyzed 1 year after therapy. All patients underwent biomarker analysis and 2D echocardiography consisting of conventional echocardiographic and strain (rate) parameters. Conventional echocardiographic values were normal. Global longitudinal strain was normal, but 18 % of patients showed a > 2 SD decrease when individually compared to reference values. This subgroup showed a decrease in end-systolic and end-diastolic volumes and an increase in left ventricular mass. Radial and circumferential strain rates were significantly decreased in the whole study group. 2D myocardial strain (rate) imaging showed abnormalities in breast cancer survivors, while conventional echocardiographic values remained normal, rendering 2D myocardial strain (rate) imaging an interesting tool for the early detection of anthracycline-induced cardiotoxicity
U2 - https://doi.org/10.1007/s10549-014-2997-4
DO - https://doi.org/10.1007/s10549-014-2997-4
M3 - Article
C2 - 24852071
SN - 0167-6806
VL - 146
SP - 127
EP - 135
JO - Breast cancer research and treatment
JF - Breast cancer research and treatment
IS - 1
ER -