Immunogenicity does not influence treatment with etanercept in patients with ankylosing spondylitis

M.K. de Vries; I.E. van der Horst-Bruinsma; M.T. Nurmohamed; L.A. Aarden; S.O. Stapel; M.J.L. Peters; J.C. van Denderen; B.A.C. Dijkmans; G.J. Wolbink; S.N. Stapel; A.C. van Denderen

doi:https://doi.org/10.1136/ard.2008.089979

Immunogenicity does not influence treatment with etanercept in patients with ankylosing spondylitis

M.K. de Vries, I.E. van der Horst-Bruinsma, M.T. Nurmohamed, L.A. Aarden, S.O. Stapel, M.J.L. Peters, J.C. van Denderen, B.A.C. Dijkmans, G.J. Wolbink, S.N. Stapel, A.C. van Denderen

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Abstract

BACKGROUND: Immunogenicity, specifically the onset of antibodies against tumour necrosis factor (TNF) blocking agents, seems to play an important role in non-response to treatment with these drugs. OBJECTIVES: To assess the relation of clinical response of ankylosing spondylitis (AS) to etanercept with etanercept levels, and the presence of antibodies to etanercept. METHODS: Patients with AS were treated with etanercept 25 mg twice weekly, according to the international Assessment in Ankylosing Spondylitis (ASAS) working group consensus statement. Sera were collected at baseline and after 3 and 6 months of treatment. Clinical response was defined as a 50% improvement or as an absolute improvement of 2 points on a (0-10 scale) Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score. Functional etanercept levels were measured by a newly developed ELISA, measuring the binding of etanercept to TNF. Antibodies against etanercept were measured with a two-site assay and antigen binding test. Clinical data were used to correlate disease activity with serum etanercept levels. RESULTS: In all, 53 consecutive patients were included. After 3 months of treatment 40 patients (76%) fulfilled the response criteria. Mean etanercept levels were 2.7 mg/litre and 3.0 mg/litre after 3 and 6 months respectively. Characteristics and etanercept levels of responders and non-responders were similar. No antibodies to etanercept were detected with any of the assays. CONCLUSION: Etanercept levels of responders and non-responders were similar and no antibodies to etanercept were detected with any of the assays. This study indicates that etanercept is much less immunogenic compared with the other TNF-blocking agents

Original language	Undefined/Unknown
Pages (from-to)	531-535
Number of pages	4
Journal	Annals of the rheumatic diseases
Volume	68
Issue number	4
DOIs	https://doi.org/10.1136/ard.2008.089979
Publication status	Published - 2009

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de Vries, M. K., van der Horst-Bruinsma, I. E., Nurmohamed, M. T., Aarden, L. A., Stapel, S. O., Peters, M. J. L., van Denderen, J. C., Dijkmans, B. A. C., Wolbink, G. J., Stapel, S. N., & van Denderen, A. C. (2009). Immunogenicity does not influence treatment with etanercept in patients with ankylosing spondylitis. Annals of the rheumatic diseases, 68(4), 531-535. https://doi.org/10.1136/ard.2008.089979

@article{ed904934a95142039f8310ada05ce8ff,

title = "Immunogenicity does not influence treatment with etanercept in patients with ankylosing spondylitis",

abstract = "BACKGROUND: Immunogenicity, specifically the onset of antibodies against tumour necrosis factor (TNF) blocking agents, seems to play an important role in non-response to treatment with these drugs. OBJECTIVES: To assess the relation of clinical response of ankylosing spondylitis (AS) to etanercept with etanercept levels, and the presence of antibodies to etanercept. METHODS: Patients with AS were treated with etanercept 25 mg twice weekly, according to the international Assessment in Ankylosing Spondylitis (ASAS) working group consensus statement. Sera were collected at baseline and after 3 and 6 months of treatment. Clinical response was defined as a 50% improvement or as an absolute improvement of 2 points on a (0-10 scale) Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score. Functional etanercept levels were measured by a newly developed ELISA, measuring the binding of etanercept to TNF. Antibodies against etanercept were measured with a two-site assay and antigen binding test. Clinical data were used to correlate disease activity with serum etanercept levels. RESULTS: In all, 53 consecutive patients were included. After 3 months of treatment 40 patients (76%) fulfilled the response criteria. Mean etanercept levels were 2.7 mg/litre and 3.0 mg/litre after 3 and 6 months respectively. Characteristics and etanercept levels of responders and non-responders were similar. No antibodies to etanercept were detected with any of the assays. CONCLUSION: Etanercept levels of responders and non-responders were similar and no antibodies to etanercept were detected with any of the assays. This study indicates that etanercept is much less immunogenic compared with the other TNF-blocking agents",

author = "{de Vries}, M.K. and {van der Horst-Bruinsma}, I.E. and M.T. Nurmohamed and L.A. Aarden and S.O. Stapel and M.J.L. Peters and {van Denderen}, J.C. and B.A.C. Dijkmans and G.J. Wolbink and S.N. Stapel and {van Denderen}, A.C.",

year = "2009",

doi = "https://doi.org/10.1136/ard.2008.089979",

language = "Undefined/Unknown",

volume = "68",

pages = "531--535",

journal = "Annals of the rheumatic diseases",

issn = "0003-4967",

publisher = "BMJ Publishing Group",

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de Vries, MK, van der Horst-Bruinsma, IE , Nurmohamed, MT, Aarden, LA, Stapel, SO, Peters, MJL, van Denderen, JC, Dijkmans, BAC , Wolbink, GJ , Stapel, SN & van Denderen, AC 2009, 'Immunogenicity does not influence treatment with etanercept in patients with ankylosing spondylitis', Annals of the rheumatic diseases, vol. 68, no. 4, pp. 531-535. https://doi.org/10.1136/ard.2008.089979

TY - JOUR

T1 - Immunogenicity does not influence treatment with etanercept in patients with ankylosing spondylitis

AU - de Vries, M.K.

AU - van der Horst-Bruinsma, I.E.

AU - Nurmohamed, M.T.

AU - Aarden, L.A.

AU - Stapel, S.O.

AU - Peters, M.J.L.

AU - van Denderen, J.C.

AU - Dijkmans, B.A.C.

AU - Wolbink, G.J.

AU - Stapel, S.N.

AU - van Denderen, A.C.

PY - 2009

Y1 - 2009

N2 - BACKGROUND: Immunogenicity, specifically the onset of antibodies against tumour necrosis factor (TNF) blocking agents, seems to play an important role in non-response to treatment with these drugs. OBJECTIVES: To assess the relation of clinical response of ankylosing spondylitis (AS) to etanercept with etanercept levels, and the presence of antibodies to etanercept. METHODS: Patients with AS were treated with etanercept 25 mg twice weekly, according to the international Assessment in Ankylosing Spondylitis (ASAS) working group consensus statement. Sera were collected at baseline and after 3 and 6 months of treatment. Clinical response was defined as a 50% improvement or as an absolute improvement of 2 points on a (0-10 scale) Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score. Functional etanercept levels were measured by a newly developed ELISA, measuring the binding of etanercept to TNF. Antibodies against etanercept were measured with a two-site assay and antigen binding test. Clinical data were used to correlate disease activity with serum etanercept levels. RESULTS: In all, 53 consecutive patients were included. After 3 months of treatment 40 patients (76%) fulfilled the response criteria. Mean etanercept levels were 2.7 mg/litre and 3.0 mg/litre after 3 and 6 months respectively. Characteristics and etanercept levels of responders and non-responders were similar. No antibodies to etanercept were detected with any of the assays. CONCLUSION: Etanercept levels of responders and non-responders were similar and no antibodies to etanercept were detected with any of the assays. This study indicates that etanercept is much less immunogenic compared with the other TNF-blocking agents

AB - BACKGROUND: Immunogenicity, specifically the onset of antibodies against tumour necrosis factor (TNF) blocking agents, seems to play an important role in non-response to treatment with these drugs. OBJECTIVES: To assess the relation of clinical response of ankylosing spondylitis (AS) to etanercept with etanercept levels, and the presence of antibodies to etanercept. METHODS: Patients with AS were treated with etanercept 25 mg twice weekly, according to the international Assessment in Ankylosing Spondylitis (ASAS) working group consensus statement. Sera were collected at baseline and after 3 and 6 months of treatment. Clinical response was defined as a 50% improvement or as an absolute improvement of 2 points on a (0-10 scale) Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score. Functional etanercept levels were measured by a newly developed ELISA, measuring the binding of etanercept to TNF. Antibodies against etanercept were measured with a two-site assay and antigen binding test. Clinical data were used to correlate disease activity with serum etanercept levels. RESULTS: In all, 53 consecutive patients were included. After 3 months of treatment 40 patients (76%) fulfilled the response criteria. Mean etanercept levels were 2.7 mg/litre and 3.0 mg/litre after 3 and 6 months respectively. Characteristics and etanercept levels of responders and non-responders were similar. No antibodies to etanercept were detected with any of the assays. CONCLUSION: Etanercept levels of responders and non-responders were similar and no antibodies to etanercept were detected with any of the assays. This study indicates that etanercept is much less immunogenic compared with the other TNF-blocking agents

U2 - https://doi.org/10.1136/ard.2008.089979

DO - https://doi.org/10.1136/ard.2008.089979

M3 - Article

C2 - 18375542

SN - 0003-4967

VL - 68

SP - 531

EP - 535

JO - Annals of the rheumatic diseases

JF - Annals of the rheumatic diseases

IS - 4

ER -