TY - JOUR
T1 - Effect of a Multi-Strain Probiotic on the Incidence and Severity of Necrotizing Enterocolitis and Feeding Intolerances in Preterm Neonates
AU - Sowden, Marwyn
AU - van Weissenbruch, Mirjam Maria
AU - Bulabula, Andre Nyandwe Hamama
AU - van Wyk, Lizelle
AU - Twisk, Jos
AU - van Niekerk, Evette
N1 - Funding Information: This research was funded by the South African Medical Research Council, Harry Crossley Foundation and VU University of Amsterdam. Publisher Copyright: © 2022 by the authors.
PY - 2022/8/12
Y1 - 2022/8/12
N2 - Background: Necrotizing enterocolitis (NEC) is a multifactorial disease, causing inflammation of the bowel. The exact root of NEC is still unknown, but a low weight and gestational age at birth are known causes. Furthermore, antibiotic use and abnormal bacterial colonization of the premature gut are possible causes. Premature neonates often experience feeding intolerances that disrupts the nutritional intake, leading to poor growth and neurodevelopmental impairment. Methods: We conducted a double-blind, placebo-controlled, randomized clinical trial to investigate the effect of a multi-strain probiotic formulation (Labinic TM) on the incidence and severity of NEC and feeding intolerances in preterm neonates. Results: There were five neonates in the placebo group who developed NEC (Stage 1A–3B), compared to no neonates in the probiotic group. Further, the use of probiotics showed a statistically significant reduction in the development of feeding intolerances, p < 0.001. Conclusion: A multi-strain probiotic is a safe and cost-effective way of preventing NEC and feeding intolerances in premature neonates.
AB - Background: Necrotizing enterocolitis (NEC) is a multifactorial disease, causing inflammation of the bowel. The exact root of NEC is still unknown, but a low weight and gestational age at birth are known causes. Furthermore, antibiotic use and abnormal bacterial colonization of the premature gut are possible causes. Premature neonates often experience feeding intolerances that disrupts the nutritional intake, leading to poor growth and neurodevelopmental impairment. Methods: We conducted a double-blind, placebo-controlled, randomized clinical trial to investigate the effect of a multi-strain probiotic formulation (Labinic TM) on the incidence and severity of NEC and feeding intolerances in preterm neonates. Results: There were five neonates in the placebo group who developed NEC (Stage 1A–3B), compared to no neonates in the probiotic group. Further, the use of probiotics showed a statistically significant reduction in the development of feeding intolerances, p < 0.001. Conclusion: A multi-strain probiotic is a safe and cost-effective way of preventing NEC and feeding intolerances in premature neonates.
KW - feeding intolerance
KW - necrotizing enterocolitis
KW - neonate
KW - probiotic
UR - http://www.scopus.com/inward/record.url?scp=85136706892&partnerID=8YFLogxK
U2 - https://doi.org/10.3390/nu14163305
DO - https://doi.org/10.3390/nu14163305
M3 - Article
C2 - 36014810
SN - 2072-6643
VL - 14
JO - NUTRIENTS
JF - NUTRIENTS
IS - 16
M1 - 3305
ER -