TY - JOUR
T1 - Effect of Coronary Artery Disease on COVID-19—Prognosis and Risk Assessment
T2 - A Systematic Review and Meta-Analysis
AU - Szarpak, Lukasz
AU - Mierzejewska, Malgorzata
AU - Jurek, Jonasz
AU - Kochanowska, Anna
AU - Gasecka, Aleksandra
AU - Truszewski, Zenon
AU - Pruc, Michal
AU - Blek, Natasza
AU - Rafique, Zubaid
AU - Filipiak, Krzysztof J.
AU - Denegri, Andrea
AU - Jaguszewski, Milosz J.
N1 - Funding Information: Acknowledgments: The study was supported by the Polish Society Disaster Medicine. A. Gasecka, M.J. Jaguszewski and L. Szarpak acknowledge the CLEVERHEART Interventional Core Laboratories. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/2/1
Y1 - 2022/2/1
N2 - Coronary artery disease (CAD) is the leading cause of death worldwide. Patients with pre-existing CAD were shown to have a more severe course of COVID-19, but this association has not been clarified. We performed a meta-analysis to determine the association between CAD and COVID-19 outcomes. We searched Scopus, Medline (PubMed), Web of Science, Embase, and Cochrane databases up to November 2nd, 2021. There were 62 studies with a total population of 49,286 patients included in the meta-analysis. CAD occurrence in survivor vs. non-survivor groups varied and amounted to 9.2% vs. 22.9%, respectively (OR = 0.33; 95%CI: 0.29 to 0.39; I2 = 70%; p < 0.001). CAD was also associated with increased severity of COVID-19 disease and was (10.8% vs. 5.6%, respectively, for severe vs. non-severe groups (OR = 2.28; 95%CI: 1.59 to 3.27; I2 = 72%; p < 0.001). The role of history of CAD in mortality and severe condition in COVID-19 presents itself as prominent—although a risk of bias in retrospective trials needs to be assessed, in case of our metaanalysis the statistically significant results when it comes to higher mortality among patients with CAD compared to non-CAD patients, a more severe condition observed in patients with CAD, and a visibly more frequent admission to intensive care unit in patients with CAD, it seems that an incidence of cardiovascular events plays a role in COVID-19 prognosis.
AB - Coronary artery disease (CAD) is the leading cause of death worldwide. Patients with pre-existing CAD were shown to have a more severe course of COVID-19, but this association has not been clarified. We performed a meta-analysis to determine the association between CAD and COVID-19 outcomes. We searched Scopus, Medline (PubMed), Web of Science, Embase, and Cochrane databases up to November 2nd, 2021. There were 62 studies with a total population of 49,286 patients included in the meta-analysis. CAD occurrence in survivor vs. non-survivor groups varied and amounted to 9.2% vs. 22.9%, respectively (OR = 0.33; 95%CI: 0.29 to 0.39; I2 = 70%; p < 0.001). CAD was also associated with increased severity of COVID-19 disease and was (10.8% vs. 5.6%, respectively, for severe vs. non-severe groups (OR = 2.28; 95%CI: 1.59 to 3.27; I2 = 72%; p < 0.001). The role of history of CAD in mortality and severe condition in COVID-19 presents itself as prominent—although a risk of bias in retrospective trials needs to be assessed, in case of our metaanalysis the statistically significant results when it comes to higher mortality among patients with CAD compared to non-CAD patients, a more severe condition observed in patients with CAD, and a visibly more frequent admission to intensive care unit in patients with CAD, it seems that an incidence of cardiovascular events plays a role in COVID-19 prognosis.
KW - CAD
KW - COVID-19
KW - Coronary artery disease
KW - Novel coronavirus
KW - Systematic review
UR - http://www.scopus.com/inward/record.url?scp=85124269277&partnerID=8YFLogxK
U2 - https://doi.org/10.3390/biology11020221
DO - https://doi.org/10.3390/biology11020221
M3 - Article
C2 - 35205088
SN - 2079-7737
VL - 11
JO - Biology
JF - Biology
IS - 2
M1 - 221
ER -