Effect of daily vitamin B-12 and folic acid supplementation on fracture incidence in elderly individuals with an elevated plasma homocysteine concentration: B-PROOF, a randomized controlled trial

J.P. van Wijngaarden, K.M.A. Swart, A.W. Enneman, R.A.M. Dhonukshe-Rutten, S.C. van Dijk, A.C. van der Ham, E.M. Brouwer-Brolsma, N.L. van der Zwaluw, L. Sohl, J.B.J. van Meurs, M.C. Zillikens, N.M. van Schoor, N. van der Velde, J. Brug, A. G. Uitterlinden, P.T.A.M. Lips, L.C.P.G. de Groot

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Background: Elevated plasma homocysteine concentrations are a risk factor for osteoporotic fractures. Lowering homocysteine with combined vitamin B-12 and folic acid supplementation may reduce fracture risk.
Original languageEnglish
Pages (from-to)1578-1586
JournalAmerican Journal of Clinical Nutrition
Issue number6
Publication statusPublished - 2014

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