TY - JOUR
T1 - Effectiveness of inhibition of cholesteryl ester transfer protein by JTT-705 in combination with Pravastatin in type II dyslipidemia
AU - Kuivenhoven, Jan Albert
AU - de Grooth, Greetje J.
AU - Kawamura, Hitoshi
AU - Klerkx, Anke H.
AU - Wilhelm, Francois
AU - Trip, Mieke D.
AU - Kastelein, John J. P.
PY - 2005
Y1 - 2005
N2 - The inhibition of cholesteryl ester transfer protein (CETP) has recently been shown to effectively increase high-density lipoprotein (HDL) cholesterol. This study examined the use of the CETP inhibitor JTT-705 combined with pravastatin. In a randomized, double-blind, placebo-controlled trial, 155 patients with type II dyslipidemia using pravastatin 40 mg were treated with placebo or JTT-705 300 or 600 mg. Four weeks of treatment with JTT-705 600 mg led to a 30% decrease in CETP activity (p <0.001), a 28% increase in HDL cholesterol (p <0.001), and a 5% decrease in low-density lipoprotein cholesterol (p <0.03). Combination therapy using JTT-705 and pravastatin effectively increases HDL cholesterol levels and is safe and well tolerated up to 4 weeks of administration. (c) 2005 by Excerpta Medical Inc
AB - The inhibition of cholesteryl ester transfer protein (CETP) has recently been shown to effectively increase high-density lipoprotein (HDL) cholesterol. This study examined the use of the CETP inhibitor JTT-705 combined with pravastatin. In a randomized, double-blind, placebo-controlled trial, 155 patients with type II dyslipidemia using pravastatin 40 mg were treated with placebo or JTT-705 300 or 600 mg. Four weeks of treatment with JTT-705 600 mg led to a 30% decrease in CETP activity (p <0.001), a 28% increase in HDL cholesterol (p <0.001), and a 5% decrease in low-density lipoprotein cholesterol (p <0.03). Combination therapy using JTT-705 and pravastatin effectively increases HDL cholesterol levels and is safe and well tolerated up to 4 weeks of administration. (c) 2005 by Excerpta Medical Inc
U2 - https://doi.org/10.1016/j.amjcard.2004.12.064
DO - https://doi.org/10.1016/j.amjcard.2004.12.064
M3 - Article
C2 - 15842977
SN - 0002-9149
VL - 95
SP - 1085
EP - 1088
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 9
ER -