Effects of Dietary Supplementation with Carrot-Derived Rhamnogalacturonan-I (cRG-I) on Accelerated Protective Immune Responses and Quality of Life in Healthy Volunteers Challenged with Rhinovirus in a Randomized Trial

Sue McKay, Annemarie Teitsma-Jansen, Esther Floris, Tamara Dekker, Barbara Smids, Ridha Khurshid, Wim Calame, Alwine Kardinaal, René Lutter, Ruud Albers

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)


An adequate and balanced supply of nutrients is essential for maintaining health, and an optimal immune response is fast, contained and properly controlled, curbing infections quickly while minimizing damage. Several micronutrients contribute to normal immune function and certain dietary fibers, for example pectic polysaccharides, can play an important role in educating and regulating immune cell responses. The aim of this paper is to elaborate on our initial findings that dietary supplementation with carrot-derived rhamnogalacturonan-I (cRG-I) accelerates and augments local innate immune and anti-viral interferon response to a rhinovirus-16 (RV16) infection and reduces the severity and duration of symptoms in humans. Dietary intake of cRG-I also enhanced immune responses to this respiratory viral infection as measured by ex vivo stimulation of whole blood with the Toll-like receptor 3 (TLR3) ligand polyinosinic:polycytidylic acid and NK cell function. Consumption of cRG-I also reduced the negative effects of this common cold infection on quality of life as assessed by individual symptom scores. RG-I from carrot is a safe, sustainable, and economically viable solution that could easily be integrated into food products and dietary supplements aiming to support immune fitness and wellbeing.
Original languageEnglish
Article number4258
Issue number20
Publication statusPublished - 1 Oct 2022


  • Jackson score
  • RG-I
  • WURSS-21
  • common cold
  • healthy adults
  • innate immune
  • quality of life
  • rhinovirus-16

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