Effects of ibopamine on the increase in plasma norepinephrine levels during exercise in congestive heart failure

Dirk J. van Veldhuisen, Armand R.J. Girbes, Stan A.J. van den Broek, Pieter A. de Graeff, Wiek H. van Gilst, K. I. Lie

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Congestive heart failure (CHF) is accompanied by increased levels of plasma norepinephrine (PNE) at rest. During exercise, PNE levels increase rapidly in patients with CHF,1 causing skeletal vasoconstriction and muscle underperfusion. Because long-term sympathetic activation may be detrimental in patients with CHF,2 inhibition of this sympathetic drive would appear to be beneficial. The oral dopamine agonist ibopamine causes vasodilation and reduces PNE levels at rest in patients with CHF.3 However, the influence of ibopamine on peak oxygen consumption (VO2) and PNE levels during exercise in patients with CHF is unknown, and was investigated in this study.

Original languageEnglish
Pages (from-to)992-994
Number of pages3
JournalThe American Journal of Cardiology
Issue number11
Publication statusPublished - 15 Apr 1993

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