Effects of local hyperthermia on the motor function of the rat sciatic nerve

J Wondergem, J Haveman, V Rusman, P Sminia, J D Van Dijk

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The effect of local heat treatment of the sciatic nerve was assessed using the toe-spreading test, which mainly assesses the motor function of the sciatic nerve. A 5 mm long segment of the nerve was heated at temperatures from 42.0 to 45.0 degrees C in vivo using a brass thermode. Hyperthermia led to a decrease in spreading of the toes. Recovery from functional loss took place in all cases, and this recovery was completed in 4 weeks. A 50 per cent functional loss in 50 per cent of the treated animals was observed after 58, 32 and 12 min of heating at 43.0, 44.0 and 45.0 degrees C respectively.

Original languageEnglish
Pages (from-to)429-38
Number of pages10
JournalInternational journal of radiation biology and related studies in physics, chemistry, and medicine
Issue number3
Publication statusPublished - Mar 1988


  • Animals
  • Female
  • Hot Temperature/adverse effects
  • Humans
  • Movement
  • Muscles/innervation
  • Rats
  • Sciatic Nerve/physiology
  • Toes/physiology

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