Effects of Two-Year Vitamin B12 and Folic Acid Supplementation on Depressive Symptoms and Quality of Life in Older Adults with Elevated Homocysteine Concentrations: Additional Results from the B-PROOF Study, an RCT

Elisa J. de Koning; Nikita L. van der Zwaluw; Janneke P. van Wijngaarden; Evelien Sohl; Elske M. Brouwer-Brolsma; Harm W. J. van Marwijk; Anke W. Enneman; Karin M. A. Swart; Suzanne C. van Dijk; Annelies C. Ham; Nathalie van der Velde; Andre G. Uitterlinden; Brenda W. J. H. Penninx; Petra J. M. Elders; Paul Lips; Rosalie A. M. Dhonukshe-Rutten; Natasja M. van Schoor; Lisette C. P. G. M. de Groot

doi:https://doi.org/10.3390/nu8110748

Effects of Two-Year Vitamin B12 and Folic Acid Supplementation on Depressive Symptoms and Quality of Life in Older Adults with Elevated Homocysteine Concentrations: Additional Results from the B-PROOF Study, an RCT

Elisa J. de Koning, Nikita L. van der Zwaluw, Janneke P. van Wijngaarden, Evelien Sohl, Elske M. Brouwer-Brolsma, Harm W. J. van Marwijk, Anke W. Enneman, Karin M. A. Swart, Suzanne C. van Dijk, Annelies C. Ham, Nathalie van der Velde, Andre G. Uitterlinden, Brenda W. J. H. Penninx, Petra J. M. Elders, Paul Lips, Rosalie A. M. Dhonukshe-Rutten, Natasja M. van Schoor, Lisette C. P. G. M. de Groot

Research output: Contribution to journal › Article › Academic › peer-review

45 Citations (Scopus)

Original language	English
Article number	E748
Journal	NUTRIENTS
Volume	8
Issue number	11
DOIs	https://doi.org/10.3390/nu8110748
Publication status	Published - Nov 2016

Keywords

depressive symptoms
folic acid
homocysteine
hyperhomocysteinemia
older adults
quality of life
randomized controlled trial
vitamin B-12

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https://doi.org/10.3390/nu8110748

Cite this

de Koning, E. J., van der Zwaluw, N. L., van Wijngaarden, J. P., Sohl, E., Brouwer-Brolsma, E. M., van Marwijk, H. W. J., Enneman, A. W., Swart, K. M. A., van Dijk, S. C., Ham, A. C., van der Velde, N., Uitterlinden, A. G., Penninx, B. W. J. H., Elders, P. J. M., Lips, P., Dhonukshe-Rutten, R. A. M., van Schoor, N. M., & de Groot, L. C. P. G. M. (2016). Effects of Two-Year Vitamin B12 and Folic Acid Supplementation on Depressive Symptoms and Quality of Life in Older Adults with Elevated Homocysteine Concentrations: Additional Results from the B-PROOF Study, an RCT. NUTRIENTS, 8(11), Article E748. https://doi.org/10.3390/nu8110748

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title = "Effects of Two-Year Vitamin B12 and Folic Acid Supplementation on Depressive Symptoms and Quality of Life in Older Adults with Elevated Homocysteine Concentrations: Additional Results from the B-PROOF Study, an RCT",

keywords = "depressive symptoms, folic acid, homocysteine, hyperhomocysteinemia, older adults, quality of life, randomized controlled trial, vitamin B-12",

author = "{de Koning}, {Elisa J.} and {van der Zwaluw}, {Nikita L.} and {van Wijngaarden}, {Janneke P.} and Evelien Sohl and Brouwer-Brolsma, {Elske M.} and {van Marwijk}, {Harm W. J.} and Enneman, {Anke W.} and Swart, {Karin M. A.} and {van Dijk}, {Suzanne C.} and Ham, {Annelies C.} and {van der Velde}, Nathalie and Uitterlinden, {Andre G.} and Penninx, {Brenda W. J. H.} and Elders, {Petra J. M.} and Paul Lips and Dhonukshe-Rutten, {Rosalie A. M.} and {van Schoor}, {Natasja M.} and {de Groot}, {Lisette C. P. G. M.}",

year = "2016",

month = nov,

doi = "https://doi.org/10.3390/nu8110748",

language = "English",

volume = "8",

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issn = "2072-6643",

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de Koning, EJ, van der Zwaluw, NL, van Wijngaarden, JP, Sohl, E, Brouwer-Brolsma, EM, van Marwijk, HWJ, Enneman, AW, Swart, KMA, van Dijk, SC, Ham, AC, van der Velde, N, Uitterlinden, AG, Penninx, BWJH , Elders, PJM , Lips, P, Dhonukshe-Rutten, RAM, van Schoor, NM & de Groot, LCPGM 2016, 'Effects of Two-Year Vitamin B12 and Folic Acid Supplementation on Depressive Symptoms and Quality of Life in Older Adults with Elevated Homocysteine Concentrations: Additional Results from the B-PROOF Study, an RCT', NUTRIENTS, vol. 8, no. 11, E748. https://doi.org/10.3390/nu8110748

Effects of Two-Year Vitamin B12 and Folic Acid Supplementation on Depressive Symptoms and Quality of Life in Older Adults with Elevated Homocysteine Concentrations: Additional Results from the B-PROOF Study, an RCT. / de Koning, Elisa J.; van der Zwaluw, Nikita L.; van Wijngaarden, Janneke P. et al.
In: NUTRIENTS, Vol. 8, No. 11, E748, 11.2016.

Research output: Contribution to journal › Article › Academic › peer-review

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T1 - Effects of Two-Year Vitamin B12 and Folic Acid Supplementation on Depressive Symptoms and Quality of Life in Older Adults with Elevated Homocysteine Concentrations: Additional Results from the B-PROOF Study, an RCT

AU - de Koning, Elisa J.

AU - van der Zwaluw, Nikita L.

AU - van Wijngaarden, Janneke P.

AU - Sohl, Evelien

AU - Brouwer-Brolsma, Elske M.

AU - van Marwijk, Harm W. J.

AU - Enneman, Anke W.

AU - Swart, Karin M. A.

AU - van Dijk, Suzanne C.

AU - Ham, Annelies C.

AU - van der Velde, Nathalie

AU - Uitterlinden, Andre G.

AU - Penninx, Brenda W. J. H.

AU - Elders, Petra J. M.

AU - Lips, Paul

AU - Dhonukshe-Rutten, Rosalie A. M.

AU - van Schoor, Natasja M.

AU - de Groot, Lisette C. P. G. M.

PY - 2016/11

Y1 - 2016/11

KW - depressive symptoms

KW - folic acid

KW - homocysteine

KW - hyperhomocysteinemia

KW - older adults

KW - quality of life

KW - randomized controlled trial

KW - vitamin B-12

U2 - https://doi.org/10.3390/nu8110748

DO - https://doi.org/10.3390/nu8110748

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JO - NUTRIENTS

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de Koning EJ, van der Zwaluw NL, van Wijngaarden JP, Sohl E, Brouwer-Brolsma EM, van Marwijk HWJ et al. Effects of Two-Year Vitamin B12 and Folic Acid Supplementation on Depressive Symptoms and Quality of Life in Older Adults with Elevated Homocysteine Concentrations: Additional Results from the B-PROOF Study, an RCT. NUTRIENTS. 2016 Nov;8(11):E748. doi: https://doi.org/10.3390/nu8110748