Effects of vitamin D supplementation on metabolic and endocrine parameters in healthy premenopausal women: A randomized controlled trial

Christian Trummer, Verena Theiler-Schwetz, Martina Kollmann, Monika Wölfler, Julia Münzker, Stefan Pilz, Thomas R. Pieber, Annemieke C. Heijboer, Barbara Obermayer-Pietsch, Elisabeth Lerchbaum

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9 Citations (Scopus)


Background & aims: Vitamin D supplementation may affect glycemic as well as hormonal regulation. Thus, the aim of the current study was to investigate whether vitamin D supplementation has any significant effects on metabolic and endocrine parameters in healthy premenopausal women. Primary outcome measure was the plasma glucose area under the curve (AUCgluc). Methods: The current study was a single-center, double-blind, randomized placebo-controlled trial that was conducted at the Medical University of Graz, Austria, between March 2013 and October 2017. One-hundred and fifty healthy premenopausal women with 25-hydroxyvitamin D [25(OH)D] concentrations <75 nmol/L once weekly received either 20,000 IU of cholecalciferol or placebo (2:1 ratio) over a total of 24 weeks. Results: In total, 127 women [age 36.2 ± 8.7 years; BMI 25.3 ± 5.6 kg/m 2 ; baseline 25(OH)D 55.8 ± 19.7 nmol/L] completed the study. Vitamin D supplementation had no significant effect on AUCgluc (mean treatment effect 11.70; p = 0.069), while it had a significant treatment effect on homeostatic model assessment-insulin resistance (HOMA-IR; mean treatment effect 0.31; p = 0.019) and quantitative insulin-sensitivity check index (QUICKI; mean treatment effect −0.019; p = 0.013). There was no significant effect on the remaining secondary outcome parameters. Conclusions: In this randomized-controlled trial in healthy premenopausal women, there was a significant treatment effect of vitamin D supplementation on HOMA-IR and QUICKI, while there was no significant treatment effect on AUCgluc.
Original languageEnglish
Pages (from-to)718-726
Number of pages9
JournalClinical nutrition (Edinburgh, Scotland)
Issue number3
Early online date20 Mar 2019
Publication statusPublished - 2019


  • Insulin resistance
  • Premenopausal
  • RCT
  • Vitamin D supplementation

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