EFFICACY OF HALF-DOSE PHOTODYNAMIC THERAPY VERSUS HIGH-DENSITY SUBTHRESHOLD MICROPULSE LASER FOR TREATING PIGMENT EPITHELIAL DETACHMENTS IN CHRONIC CENTRAL SEROUS CHORIORETINOPATHY

Helena M. A. Feenstra, Leo C. Hahn, Thomas J. van Rijssen, Roula Tsonaka, Myrte B. Breukink, Jan. E. E. Keunen, Petrus J. H. Peters, Greet Dijkman, Eric H. Souied, Robert E. MacLaren, Giuseppe Querques, Susan M. Downes, Sascha Fauser, Carel B. Hoyng, Elon H. C. van Dijk, Camiel J. F. Boon

Research output: Contribution to JournalArticleAcademicpeer-review

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Abstract

Purpose:Comparing the effect of half-dose photodynamic therapy and high-density subthreshold micropulse laser treatment on retinal pigment epithelial detachments (PEDs) in chronic central serous chorioretinopathy.Methods:This study included data from the PLACE trial, a prospective randomized controlled trial comparing half-dose photodynamic therapy and high-density subthreshold micropulse laser treatment in chronic central serous chorioretinopathy. Main outcome measurements were changes in both the foveal PED and the highest PED within the macula at baseline compared with first and final evaluation visit.Results:At baseline, a macular PED was detected in 76.9% of patients (123/160), and a PED within 1,500 µm from the foveal center in 37.5% of patients (60/160). In the half-dose photodynamic therapy arm (61 patients), there was a significantly larger decrease in the highest macular PED compared with the high-density subthreshold micropulse laser treatment arm (62 patients) at both first and final evaluation visits (P < 0.001 and P = 0.012, respectively). The decrease of highest foveal PED was significant at first visit (P = 0.025).Conclusion:Half-dose photodynamic therapy is superior to high-density subthreshold micropulse laser treatment with regard to a statistically significant reduction in the height of macular PEDs in active chronic central serous chorioretinopathy. These findings may also have implications for other diseases within the pachychoroid disease spectrum that can present with PEDs.

Original languageEnglish
Pages (from-to)721-729
Number of pages9
JournalRetina (Philadelphia, Pa.)
Volume42
Issue number4
DOIs
Publication statusPublished - 1 Apr 2022

Keywords

  • PLACE trial
  • central serous chorioretinopathy
  • half-dose photodynamic therapy
  • high-density subthreshold micropulse laser
  • pigment epithelial detachment

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