Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms

G. Zhai, A. Teumer, L. Stolk, J.R. Perry, L. Vandenput, A.D. Coviello, A. Koster, J.T. Bell, S. Bhasin, J. Eriksson, A. Eriksson, F. Ernst, L. Ferrucci, T.M. Frayling, D. Glass, E. Grundberg, R. Haring, A.K. Hedman, A. Hofman, D.P. KielH.K. Kroemer, Y. Liu, K.L. Lunetta, M. Maggio, M. Lorentzon, M. Mangino, D. Melzer, I. Miljkovic, A. Nica, B.W.J.H. Penninx, R.S. Vasan, F. Rivadeneira, K.S. Small, N. Soranzo, A. G. Uitterlinden, H. Voelzke, S.G. Wilson, L. Xi, W.V. Zhuang, T.B. Harris, J.M. Murabito, C. Ohlsson, A. Murray, F.H. de Jong, T.D. Spector, H. Wallaschofski

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Abstract

Dehydroepiandrosterone sulphate (DHEAS) is the most abundant circulating steroid secreted by adrenal glands-yet its function is unknown. Its serum concentration declines significantly with increasing age, which has led to speculation that a relative DHEAS deficiency may contribute to the development of common age-related diseases or diminished longevity. We conducted a meta-analysis of genome-wide association data with 14,846 individuals and identified eight independent common SNPs associated with serum DHEAS concentrations. Genes at or near the identified loci include ZKSCAN5 (rs11761528; p = 3.15×10
Original languageEnglish
Article numbere1002025
JournalPLOS Genetics
Volume7
Issue number4
DOIs
Publication statusPublished - 2011

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