Electrical interactions between cardiac cells studied with 'model clamp'

Ronald Wilders; E. Etienne Verheijck; Rajiv Kumar; David Golod; Antoni C.G. van Ginneken; William N. Goolsby; Ronald W. Joyner; Habo J. Jongsma

Electrical interactions between cardiac cells studied with 'model clamp'

Ronald Wilders, E. Etienne Verheijck, Rajiv Kumar, David Golod, Antoni C.G. van Ginneken, William N. Goolsby, Ronald W. Joyner, Habo J. Jongsma

Research output: Contribution to conference › Paper › Academic

Abstract

We have developed a method for coupling a single isolated cardiac cell to its mathematical model counterpart by a variable artificial intercellular conductance. With this 'model clamp' technique, the model cell is coupled by any desired value of 'gap junctional conductance' to an isolated cardiac cell from which electrophysiological recordings are being made in the current clamp mode. The cell model runs on a fast personal computer and communicates bidirectionally with the real cell through a data acquisition board. We have used the model clamp technique to study synchronization of rabbit sinoatrial node cells and action potential conduction between guinea pig ventricular cells.

Original language	English
Pages	1-2
Number of pages	2
Publication status	Published - 1995
Event	Proceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2) - Montreal, Can Duration: 20 Sept 1995 → 23 Sept 1995

Conference

Conference	Proceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2)
City	Montreal, Can
Period	20/09/1995 → 23/09/1995

Cite this

Wilders, R., Verheijck, E. E., Kumar, R., Golod, D., van Ginneken, A. C. G., Goolsby, W. N., Joyner, R. W., & Jongsma, H. J. (1995). Electrical interactions between cardiac cells studied with 'model clamp'. 1-2. Paper presented at Proceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2), Montreal, Can.

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title = "Electrical interactions between cardiac cells studied with 'model clamp'",

abstract = "We have developed a method for coupling a single isolated cardiac cell to its mathematical model counterpart by a variable artificial intercellular conductance. With this 'model clamp' technique, the model cell is coupled by any desired value of 'gap junctional conductance' to an isolated cardiac cell from which electrophysiological recordings are being made in the current clamp mode. The cell model runs on a fast personal computer and communicates bidirectionally with the real cell through a data acquisition board. We have used the model clamp technique to study synchronization of rabbit sinoatrial node cells and action potential conduction between guinea pig ventricular cells.",

author = "Ronald Wilders and Verheijck, {E. Etienne} and Rajiv Kumar and David Golod and {van Ginneken}, {Antoni C.G.} and Goolsby, {William N.} and Joyner, {Ronald W.} and Jongsma, {Habo J.}",

year = "1995",

language = "English",

pages = "1--2",

note = "Proceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2) ; Conference date: 20-09-1995 Through 23-09-1995",

}

Wilders, R, Verheijck, EE, Kumar, R, Golod, D, van Ginneken, ACG, Goolsby, WN, Joyner, RW & Jongsma, HJ 1995, 'Electrical interactions between cardiac cells studied with 'model clamp'', Paper presented at Proceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2), Montreal, Can, 20/09/1995 - 23/09/1995 pp. 1-2.

Electrical interactions between cardiac cells studied with 'model clamp'. / Wilders, Ronald; Verheijck, E. Etienne; Kumar, Rajiv et al.
1995. 1-2 Paper presented at Proceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2), Montreal, Can.

Research output: Contribution to conference › Paper › Academic

TY - CONF

T1 - Electrical interactions between cardiac cells studied with 'model clamp'

AU - Wilders, Ronald

AU - Verheijck, E. Etienne

AU - Kumar, Rajiv

AU - Golod, David

AU - van Ginneken, Antoni C.G.

AU - Goolsby, William N.

AU - Joyner, Ronald W.

AU - Jongsma, Habo J.

PY - 1995

Y1 - 1995

N2 - We have developed a method for coupling a single isolated cardiac cell to its mathematical model counterpart by a variable artificial intercellular conductance. With this 'model clamp' technique, the model cell is coupled by any desired value of 'gap junctional conductance' to an isolated cardiac cell from which electrophysiological recordings are being made in the current clamp mode. The cell model runs on a fast personal computer and communicates bidirectionally with the real cell through a data acquisition board. We have used the model clamp technique to study synchronization of rabbit sinoatrial node cells and action potential conduction between guinea pig ventricular cells.

AB - We have developed a method for coupling a single isolated cardiac cell to its mathematical model counterpart by a variable artificial intercellular conductance. With this 'model clamp' technique, the model cell is coupled by any desired value of 'gap junctional conductance' to an isolated cardiac cell from which electrophysiological recordings are being made in the current clamp mode. The cell model runs on a fast personal computer and communicates bidirectionally with the real cell through a data acquisition board. We have used the model clamp technique to study synchronization of rabbit sinoatrial node cells and action potential conduction between guinea pig ventricular cells.

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M3 - Paper

SP - 1

EP - 2

T2 - Proceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2)

Y2 - 20 September 1995 through 23 September 1995

ER -

Electrical interactions between cardiac cells studied with 'model clamp'

Abstract

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