TY - JOUR
T1 - Elements of morphology: Standard terminology for the teeth and classifying genetic dental disorders
AU - International Group of Dental Nomenclature
AU - de la Dure-Molla, Muriel
AU - Fournier, Benjamin Philippe
AU - Manzanares, Maria Cristina
AU - Acevedo, Ana Carolina
AU - Hennekam, Raoul C.
AU - Friedlander, Lisa
AU - Boy-Lefèvre, Marie-Laure
AU - Kerner, Stephane
AU - Toupenay, Steve
AU - Garrec, Pascal
AU - Vi-Fane, Brigite
AU - Felizardo, Rufino
AU - Berteretche, Marie-Violaine
AU - Jordan, Laurence
AU - Ferré, François
AU - Clauss, François
AU - Jung, Sophie
AU - de Chalendar, Myriam
AU - Troester, Sebastien
AU - Kawczynski, Marzena
AU - Chaloyard, Jessica
AU - Manière, Marie C. cile
AU - Berdal, Ariane
AU - Bloch-Zupan, Agnès
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Dental anomalies occur frequently in a number of genetic disorders and act as major signs in diagnosing these disorders. We present definitions of the most common dental signs and propose a classification usable as a diagnostic tool by dentists, clinical geneticists, and other health care providers. The definitions are part of the series Elements of Morphology and have been established after careful discussions within an international group of experienced dentists and geneticists. The classification system was elaborated in the French collaborative network “TÊTECOU” and the affiliated O-Rares reference/competence centers. The classification includes isolated and syndromic disorders with oral and dental anomalies, to which causative genes and main extraoral signs and symptoms are added. A systematic literature analysis yielded 408 entities of which a causal gene has been identified in 79%. We classified dental disorders in eight groups: dental agenesis, supernumerary teeth, dental size and/or shape, enamel, dentin, dental eruption, periodontal and gingival, and tumor-like anomalies. We aim the classification to act as a shared reference for clinical and epidemiological studies. We welcome critical evaluations of the definitions and classification and will regularly update the classification for newly recognized conditions.
AB - Dental anomalies occur frequently in a number of genetic disorders and act as major signs in diagnosing these disorders. We present definitions of the most common dental signs and propose a classification usable as a diagnostic tool by dentists, clinical geneticists, and other health care providers. The definitions are part of the series Elements of Morphology and have been established after careful discussions within an international group of experienced dentists and geneticists. The classification system was elaborated in the French collaborative network “TÊTECOU” and the affiliated O-Rares reference/competence centers. The classification includes isolated and syndromic disorders with oral and dental anomalies, to which causative genes and main extraoral signs and symptoms are added. A systematic literature analysis yielded 408 entities of which a causal gene has been identified in 79%. We classified dental disorders in eight groups: dental agenesis, supernumerary teeth, dental size and/or shape, enamel, dentin, dental eruption, periodontal and gingival, and tumor-like anomalies. We aim the classification to act as a shared reference for clinical and epidemiological studies. We welcome critical evaluations of the definitions and classification and will regularly update the classification for newly recognized conditions.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85071368003&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/31468724
UR - http://www.scopus.com/inward/record.url?scp=85071368003&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/ajmg.a.61316
DO - https://doi.org/10.1002/ajmg.a.61316
M3 - Article
C2 - 31468724
SN - 1552-4825
VL - 179
SP - 1913
EP - 1981
JO - American Journal of Medical Genetics, Part A
JF - American Journal of Medical Genetics, Part A
IS - 10
ER -