Elevated C-reactive protein levels during first trimester of pregnancy are indicative of preeclampsia and intrauterine growth restriction

M L Tjoa, J M G van Vugt, A T J J Go, M A Blankenstein, C B M Oudejans, I J van Wijk

Research output: Contribution to journalArticleAcademicpeer-review

59 Citations (Scopus)


C-reactive protein (CRP) is a marker of tissue damage and inflammation. Maternal levels of CRP are elevated in overt preeclampsia, but there is still debate about its use as a predictive marker for preeclampsia during the first and second trimesters of pregnancy. In this study, we measured CRP levels during the first trimester of pregnancy in women who later developed preeclampsia or gave birth to a growth-restricted baby. In total, 107 women from a low-risk population participated in the study, six women developed preeclampsia and nine gave birth to a growth-restricted baby. Although there is a large overlap in measured CRP levels between the three groups, mean CRP levels were significantly elevated in women who later developed preeclampsia (P=0.031) or delivered a growth-restricted baby (P=0.041) when compared with women from the control group, matched for maternal and gestational age, parity, and gravidity. This study shows that in a low-risk population, CRP levels are already elevated between weeks 10 and 14 in pregnant women who develop preeclampsia or deliver a growth-restricted baby.

Original languageEnglish
Pages (from-to)29-37
Number of pages9
JournalJournal of Reproductive Immunology
Issue number1
Publication statusPublished - Jun 2003


  • Birth Weight
  • Blood Pressure
  • C-Reactive Protein/metabolism
  • Case-Control Studies
  • Female
  • Fetal Growth Retardation/blood
  • Humans
  • Infant, Newborn
  • Organ Size
  • Placenta/blood supply
  • Pre-Eclampsia/blood
  • Pregnancy
  • Pregnancy Complications, Cardiovascular/blood
  • Pregnancy Trimester, First/blood

Cite this