TY - JOUR
T1 - Ellipro scores of donor epitope specific HLA antibodies are not associated with kidney graft survival
AU - Kardol-Hoefnagel, Tineke
AU - Senejohnny, Danial Mohammadi
AU - Kamburova, Elena G.
AU - Wisse, Bram W.
AU - Gruijters, Maartje L.
AU - Joosten, Irma
AU - Allebes, Wil A.
AU - van der Meer, Arnold
AU - Hilbrands, Luuk B.
AU - Baas, Marije C.
AU - Spierings, Eric
AU - Hack, Cornelis E.
AU - van Reekum, Franka E.
AU - van Zuilen, Arjan D.
AU - Verhaar, Marianne C.
AU - Drop, Adriaan C. A. D.
AU - Plaisier, Loes
AU - Melchers, Rowena C. A.
AU - Seelen, Marc A. J.
AU - Sanders, Jan Stephan
AU - Hepkema, Bouke G.
AU - Kroesen, Bart-Jan
AU - Bungener, Laura B.
AU - Roozendaal, Caroline
AU - Tilanus, Marcel G. J.
AU - Voorter, Christina E.
AU - Wieten, Lotte
AU - van Duijnhoven, Elly M.
AU - Gelens, Mariëlle A. C. J.
AU - Christiaans, Maarten H. L.
AU - van Ittersum, Frans J.
AU - Nurmohamed, Shaikh A.
AU - Lardy, Neubury M.
AU - Swelsen, Wendy
AU - van der Pant, Karlijn A. M. I.
AU - van der Weerd, Neelke C.
AU - ten Berge, Ineke J. M.
AU - Hoitsma, Andries
AU - van der Boog, Paul J. M.
AU - de Fijter, Johan W.
AU - Betjes, Michiel G. H.
AU - Roelen, Dave L.
AU - Claas, Frans H.
AU - Bemelman, Frederike J.
AU - Heidt, Sebastiaan
AU - Otten, Henny G.
N1 - Publisher Copyright: © 2023 The Authors. HLA: Immune Response Genetics published by John Wiley & Sons Ltd.
PY - 2024/1/1
Y1 - 2024/1/1
N2 - In kidney transplantation, donor HLA antibodies are a risk factor for graft loss. Accessibility of donor eplets for HLA antibodies is predicted by the ElliPro score. The clinical usefulness of those scores in relation to transplant outcome is unknown. In a large Dutch kidney transplant cohort, Ellipro scores of pretransplant donor antibodies that can be assigned to known eplets (donor epitope specific HLA antibodies [DESAs]) were compared between early graft failure and long surviving deceased donor transplants. We did not observe a significant Ellipro score difference between the two cohorts, nor significant differences in graft survival between transplants with DESAs having high versus low total Ellipro scores. We conclude that Ellipro scores cannot be used to identify DESAs associated with early versus late kidney graft loss in deceased donor transplants.
AB - In kidney transplantation, donor HLA antibodies are a risk factor for graft loss. Accessibility of donor eplets for HLA antibodies is predicted by the ElliPro score. The clinical usefulness of those scores in relation to transplant outcome is unknown. In a large Dutch kidney transplant cohort, Ellipro scores of pretransplant donor antibodies that can be assigned to known eplets (donor epitope specific HLA antibodies [DESAs]) were compared between early graft failure and long surviving deceased donor transplants. We did not observe a significant Ellipro score difference between the two cohorts, nor significant differences in graft survival between transplants with DESAs having high versus low total Ellipro scores. We conclude that Ellipro scores cannot be used to identify DESAs associated with early versus late kidney graft loss in deceased donor transplants.
KW - DESA
KW - Ellipro scores
KW - kidney transplantation
UR - http://www.scopus.com/inward/record.url?scp=85181226604&partnerID=8YFLogxK
U2 - https://doi.org/10.1111/tan.15297
DO - https://doi.org/10.1111/tan.15297
M3 - Article
C2 - 38226401
SN - 2059-2302
VL - 103
JO - HLA
JF - HLA
IS - 1
M1 - e15297
ER -