Embryology, anatomy, physiology and pathophysiology of the peritoneum and the peritoneal vasculature

Arnoud W. Kastelein, Laura M. C. Vos, Kees H. de Jong, Juliette O. A. M. van Baal, Rienk Nieuwland, Cornelis J. F. van Noorden, Jan-Paul W. R. Roovers, Christianne A. R. Lok

Research output: Contribution to journalArticleAcademicpeer-review

35 Citations (Scopus)

Abstract

The peritoneum is a large serous membrane with both epithelial and mesenchymal features, and is essential for maintaining an intra-abdominal homeostatic equilibrium. The peritoneum plays a central role in the pathogenesis of a number of disorders. Pathological processes affecting the peritoneum such as inflammation and carcinomatosis can have serious clinical consequences, but the pathophysiology of these conditions is poorly understood. Understanding peritoneal embryology, anatomy and physiology is crucial to comprehend pathophysiological mechanisms and to devise a new focus for research. The vascular response to pathological processes appears to be of considerable importance, since the peritoneal vasculature plays a pivotal role in most associated diseases. Therefore, this review summarizes currently available literature with special emphasis on the development, anatomy and function of the peritoneal vasculature. Pathological processes are described to illustrate physiological and pathophysiological characteristics of the peritoneum.
Original languageEnglish
Pages (from-to)27-36
JournalSeminars in cell & developmental biology
Volume92
DOIs
Publication statusPublished - Aug 2019

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