Emerging views of the nucleus as a cellular mechanosensor

Tyler J Kirby, Jan Lammerding

Research output: Contribution to journalReview articleAcademicpeer-review

309 Citations (Scopus)


The ability of cells to respond to mechanical forces is critical for numerous biological processes. Emerging evidence indicates that external mechanical forces trigger changes in nuclear envelope structure and composition, chromatin organization and gene expression. However, it remains unclear if these processes originate in the nucleus or are downstream of cytoplasmic signals. Here we discuss recent findings that support a direct role of the nucleus in cellular mechanosensing and highlight novel tools to study nuclear mechanotransduction.

Original languageEnglish
Pages (from-to)373-381
Number of pages9
JournalNature cell biology
Issue number4
Publication statusPublished - Apr 2018


  • Animals
  • Cell Nucleus/metabolism
  • Gene Expression Regulation
  • Humans
  • Intracellular Signaling Peptides and Proteins/genetics
  • Mechanotransduction, Cellular
  • Stress, Mechanical

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