TY - JOUR
T1 - Endoplasmic reticulum: The unfolded protein response is tangled in neurodegeneration
T2 - The unfolded protein response is tangled in neurodegeneration
AU - Hoozemans, J.J.M.
AU - Scheper, W.
PY - 2012
Y1 - 2012
N2 - The endoplasmic reticulum (ER) is involved in the folding and maturation of membrane-bound and secreted proteins. Disturbed homeostasis in the ER can lead to accumulation of misfolded proteins, which trigger a stress response called the unfolded protein response (UPR). In neurodegenerative diseases that are classified as tauopathies, activation of the UPR coincides with the pathogenic accumulation of the microtubule associated protein tau. Several lines of evidence indicate that UPR activation contributes to increased levels of phosphorylated tau, a prerequisite for the formation of tau aggregates. Increased understanding of the crosstalk between signaling pathways involved in protein quality control in the ER and tau phosphorylation will support the development of new therapeutic targets that promote neuronal survival. (C) 2012 Elsevier Ltd. All rights reserved
AB - The endoplasmic reticulum (ER) is involved in the folding and maturation of membrane-bound and secreted proteins. Disturbed homeostasis in the ER can lead to accumulation of misfolded proteins, which trigger a stress response called the unfolded protein response (UPR). In neurodegenerative diseases that are classified as tauopathies, activation of the UPR coincides with the pathogenic accumulation of the microtubule associated protein tau. Several lines of evidence indicate that UPR activation contributes to increased levels of phosphorylated tau, a prerequisite for the formation of tau aggregates. Increased understanding of the crosstalk between signaling pathways involved in protein quality control in the ER and tau phosphorylation will support the development of new therapeutic targets that promote neuronal survival. (C) 2012 Elsevier Ltd. All rights reserved
U2 - https://doi.org/10.1016/j.biocel.2012.04.023
DO - https://doi.org/10.1016/j.biocel.2012.04.023
M3 - Article
C2 - 22564438
SN - 1357-2725
VL - 44
SP - 1295
EP - 1298
JO - International Journal of Biochemistry & Cell Biology
JF - International Journal of Biochemistry & Cell Biology
IS - 8
ER -