TY - JOUR
T1 - Endoscopic risk factors for neoplastic progression in patients with Barrett's oesophagus
AU - Bureo Gonzalez, Angela
AU - Bergman, Jacques Jghm
AU - Pouw, Roos E
N1 - Publisher Copyright: © 2016, © Author(s) 2016.
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Barrett's oesophagus is a precursor lesion for oesophageal adenocarcinoma, which generally has a poor prognosis. Patients diagnosed with Barrett's oesophagus therefore undergo regular endoscopic surveillance to detect neoplastic lesions at a curable stage. The efficacy of endoscopic surveillance of Barrett's oesophagus patients is, however, hampered by difficulties to detect early neoplasia endoscopically, biopsy sampling error, inter-observer variability in histological assessment and the relatively low overall progression rate. Efficacy and cost-effectiveness of Barrett's surveillance may be improved by using endoscopic and clinical characteristics to risk-stratify Barrett's patients to high- and low-risk categories. Recent national and international surveillance guidelines have incorporated Barrett's length and presence of low-grade dysplasia in the advised surveillance intervals. In this review we will discuss endoscopic characteristics that may be associated with neoplastic progression in Barrett's oesophagus and that may be used to tailor surveillance in Barrett's patients
AB - Barrett's oesophagus is a precursor lesion for oesophageal adenocarcinoma, which generally has a poor prognosis. Patients diagnosed with Barrett's oesophagus therefore undergo regular endoscopic surveillance to detect neoplastic lesions at a curable stage. The efficacy of endoscopic surveillance of Barrett's oesophagus patients is, however, hampered by difficulties to detect early neoplasia endoscopically, biopsy sampling error, inter-observer variability in histological assessment and the relatively low overall progression rate. Efficacy and cost-effectiveness of Barrett's surveillance may be improved by using endoscopic and clinical characteristics to risk-stratify Barrett's patients to high- and low-risk categories. Recent national and international surveillance guidelines have incorporated Barrett's length and presence of low-grade dysplasia in the advised surveillance intervals. In this review we will discuss endoscopic characteristics that may be associated with neoplastic progression in Barrett's oesophagus and that may be used to tailor surveillance in Barrett's patients
KW - Barrett’s oesophagus
KW - high-grade dysplasia
KW - oesophageal adenocarcinoma
KW - risk factors
KW - surveillance
UR - http://www.scopus.com/inward/record.url?scp=84988805276&partnerID=8YFLogxK
U2 - https://doi.org/10.1177/2050640616635509
DO - https://doi.org/10.1177/2050640616635509
M3 - Review article
C2 - 27733907
SN - 2050-6406
VL - 4
SP - 657
EP - 662
JO - United European gastroenterology journal
JF - United European gastroenterology journal
IS - 5
ER -