Endothelial cell metabolism in atherosclerosis

Kosta Theodorou, Reinier A. Boon

Research output: Contribution to journalArticleAcademicpeer-review

114 Citations (Scopus)

Abstract

Atherosclerosis and its sequelae, such as myocardial infarction and stroke, are the leading cause of death worldwide. Vascular endothelial cells (EC) play a critical role in vascular homeostasis and disease. Atherosclerosis as well as its independent risk factors including diabetes, obesity, and aging, are hallmarked by endothelial activation and dysfunction. Metabolic pathways have emerged as key regulators of many EC functions, including angiogenesis, inflammation, and barrier function, processes which are deregulated during atherogenesis. In this review, we highlight the role of glucose, fatty acid, and amino acid metabolism in EC functions during physiological and pathological states, specifically atherosclerosis, diabetes, obesity and aging.
Original languageEnglish
Article number82
JournalFrontiers in cell and developmental biology
Volume6
Issue numberAUG
DOIs
Publication statusPublished - 2018

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