Endothelial microRNAs and long noncoding RNAs in cardiovascular ageing

Diewertje I. Bink, Jessica Pauli, Lars Maegdefessel, Reinier A. Boon

Research output: Contribution to journalReview articleAcademicpeer-review

4 Citations (Scopus)

Abstract

Atherosclerosis and numerous other cardiovascular diseases develop in an age-dependent manner. The endothelial cells that line the vessel walls play an important role in the development of atherosclerosis. Non-coding RNA like microRNAs and long non-coding RNAs are known to play an important role in endothelial function and are implicated in the disease progression. Here, we summarize several microRNAs and long non-coding RNAs that are known to have an altered expression with endothelial aging and discuss their role in endothelial cell function and senescence. These processes contribute to aging-induced atherosclerosis development and by targeting the non-coding RNAs controlling endothelial cell function and senescence, atherosclerosis can potentially be attenuated.
Original languageEnglish
Pages (from-to)99-106
Number of pages8
JournalAtherosclerosis
Volume374
Early online date2023
DOIs
Publication statusPublished - Jun 2023

Keywords

  • Ageing
  • Endothelial cells
  • Non-coding RNA
  • lncRNA
  • microRNA

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