TY - JOUR
T1 - Endotoxaemia and postoperative hypermetabolism in coronary artery bypass surgery
T2 - The role of ketanserin
AU - Oudemans-Van Straaten, H. M.
AU - Jansen, P. G.M.
AU - Te Velthuis, H.
AU - Stoutenbeek, Chr P.
AU - Zandstra, D. F.
AU - Van Deventer, S. J.H.
AU - Sturk, A.
AU - Wildevuur, Ch R.H.
AU - Eijsman, L.
PY - 1996/1/1
Y1 - 1996/1/1
N2 - In a randomized, double-blind clinical study in 29 patients undergoing elective coronary artery surgery, we assessed the role of ketanserin, an inhibitor of serotonin-induced vasoconstriction and weak α1 sympathetic blocker, in reducing endotoxaemia and postoperative hypermetabolism. Male patients without major organ dysfunction were allocated randomly to receive either ketanserin or placebo. Hypermetabolism was defined as an increase in oxygen consumption in the early postoperative hours (ΔV̇(O2)). Circulating endotoxin (P = 0.04) and postoperative ΔV̇(O2) (P = 0.03) were lower in the ketanserin patients. Endotoxaemia was associated also with low vascular filling. From these preliminary results we conclude that treatment with ketanserin during cardiac surgery may reduce but not abolish endotoxaemia and postoperative hypermetabolism.
AB - In a randomized, double-blind clinical study in 29 patients undergoing elective coronary artery surgery, we assessed the role of ketanserin, an inhibitor of serotonin-induced vasoconstriction and weak α1 sympathetic blocker, in reducing endotoxaemia and postoperative hypermetabolism. Male patients without major organ dysfunction were allocated randomly to receive either ketanserin or placebo. Hypermetabolism was defined as an increase in oxygen consumption in the early postoperative hours (ΔV̇(O2)). Circulating endotoxin (P = 0.04) and postoperative ΔV̇(O2) (P = 0.03) were lower in the ketanserin patients. Endotoxaemia was associated also with low vascular filling. From these preliminary results we conclude that treatment with ketanserin during cardiac surgery may reduce but not abolish endotoxaemia and postoperative hypermetabolism.
KW - Complications, endotoxaemia
KW - Metabolism, oxygen consumption
KW - Oxygen, consumption
KW - Pharmacology, ketanserin
KW - Surgery, cardiovascular
UR - http://www.scopus.com/inward/record.url?scp=10244250354&partnerID=8YFLogxK
U2 - https://doi.org/10.1093/bja/77.4.473
DO - https://doi.org/10.1093/bja/77.4.473
M3 - Article
C2 - 8942331
SN - 0007-0912
VL - 77
SP - 473
EP - 479
JO - British Journal of Anaesthesia
JF - British Journal of Anaesthesia
IS - 4
ER -