Enhanced microglial pro-inflammatory response to lipopolysaccharide correlates with brain infiltration and blood-brain barrier dysregulation in a mouse model of telomere shortening

D.D. Raj, J. Moser, S.M.A. van der Pol, R.P. van Os, I.R. Holtman, N. Brouwer, H. Oeseburg, W. Schaafsma, E.M. Wesseling, W. den Dunnen, K.P. Biber, H.E. de Vries, B.J. Eggen, H.W.G.M. Boddeke

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Microglia are a proliferative population of resident brain macrophages that under physiological conditions self-renew independent of hematopoiesis. Microglia are innate immune cells actively surveying the brain and are the earliest responders to injury. During aging, microglia elicit an enhanced innate immune response also referred to as 'priming'. To date, it remains unknown whether telomere shortening affects the proliferative capacity and induces priming of microglia. We addressed this issue using early (first-generation G1 mTerc
Original languageEnglish
Pages (from-to)1003-1013
JournalAging cell
Issue number6
Publication statusPublished - 2015

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