Enhanced microglial pro-inflammatory response to lipopolysaccharide correlates with brain infiltration and blood-brain barrier dysregulation in a mouse model of telomere shortening

D.D. Raj; J. Moser; S.M.A. van der Pol; R.P. van Os; I.R. Holtman; N. Brouwer; H. Oeseburg; W. Schaafsma; E.M. Wesseling; W. den Dunnen; K.P. Biber; H.E. de Vries; B.J. Eggen; H.W.G.M. Boddeke

doi:https://doi.org/10.1111/acel.12370

Enhanced microglial pro-inflammatory response to lipopolysaccharide correlates with brain infiltration and blood-brain barrier dysregulation in a mouse model of telomere shortening

D.D. Raj, J. Moser, S.M.A. van der Pol, R.P. van Os, I.R. Holtman, N. Brouwer, H. Oeseburg, W. Schaafsma, E.M. Wesseling, W. den Dunnen, K.P. Biber, H.E. de Vries, B.J. Eggen, H.W.G.M. Boddeke

Molecular cell biology and Immunology (VUmc)

Research output: Contribution to journal › Article › Academic › peer-review

48 Citations (Scopus)

Abstract

Microglia are a proliferative population of resident brain macrophages that under physiological conditions self-renew independent of hematopoiesis. Microglia are innate immune cells actively surveying the brain and are the earliest responders to injury. During aging, microglia elicit an enhanced innate immune response also referred to as 'priming'. To date, it remains unknown whether telomere shortening affects the proliferative capacity and induces priming of microglia. We addressed this issue using early (first-generation G1 mTerc

Original language	English
Pages (from-to)	1003-1013
Journal	Aging cell
Volume	14
Issue number	6
DOIs	https://doi.org/10.1111/acel.12370
Publication status	Published - 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

https://doi.org/10.1111/acel.12370

Cite this

Raj, D. D., Moser, J., van der Pol, S. M. A., van Os, R. P., Holtman, I. R., Brouwer, N., Oeseburg, H., Schaafsma, W., Wesseling, E. M., den Dunnen, W., Biber, K. P., de Vries, H. E., Eggen, B. J., & Boddeke, H. W. G. M. (2015). Enhanced microglial pro-inflammatory response to lipopolysaccharide correlates with brain infiltration and blood-brain barrier dysregulation in a mouse model of telomere shortening. Aging cell, 14(6), 1003-1013. https://doi.org/10.1111/acel.12370

@article{73ba287ba53a4af3bff2a4ae1a550bf2,

title = "Enhanced microglial pro-inflammatory response to lipopolysaccharide correlates with brain infiltration and blood-brain barrier dysregulation in a mouse model of telomere shortening",

abstract = "Microglia are a proliferative population of resident brain macrophages that under physiological conditions self-renew independent of hematopoiesis. Microglia are innate immune cells actively surveying the brain and are the earliest responders to injury. During aging, microglia elicit an enhanced innate immune response also referred to as 'priming'. To date, it remains unknown whether telomere shortening affects the proliferative capacity and induces priming of microglia. We addressed this issue using early (first-generation G1 mTerc",

author = "D.D. Raj and J. Moser and {van der Pol}, S.M.A. and {van Os}, R.P. and I.R. Holtman and N. Brouwer and H. Oeseburg and W. Schaafsma and E.M. Wesseling and {den Dunnen}, W. and K.P. Biber and {de Vries}, H.E. and B.J. Eggen and H.W.G.M. Boddeke",

year = "2015",

doi = "https://doi.org/10.1111/acel.12370",

language = "English",

volume = "14",

pages = "1003--1013",

journal = "Aging cell",

issn = "1474-9718",

publisher = "Wiley-Blackwell",

number = "6",

}

Raj, DD, Moser, J, van der Pol, SMA, van Os, RP, Holtman, IR, Brouwer, N, Oeseburg, H, Schaafsma, W, Wesseling, EM, den Dunnen, W, Biber, KP, de Vries, HE, Eggen, BJ & Boddeke, HWGM 2015, 'Enhanced microglial pro-inflammatory response to lipopolysaccharide correlates with brain infiltration and blood-brain barrier dysregulation in a mouse model of telomere shortening', Aging cell, vol. 14, no. 6, pp. 1003-1013. https://doi.org/10.1111/acel.12370

TY - JOUR

T1 - Enhanced microglial pro-inflammatory response to lipopolysaccharide correlates with brain infiltration and blood-brain barrier dysregulation in a mouse model of telomere shortening

AU - Raj, D.D.

AU - Moser, J.

AU - van der Pol, S.M.A.

AU - van Os, R.P.

AU - Holtman, I.R.

AU - Brouwer, N.

AU - Oeseburg, H.

AU - Schaafsma, W.

AU - Wesseling, E.M.

AU - den Dunnen, W.

AU - Biber, K.P.

AU - de Vries, H.E.

AU - Eggen, B.J.

AU - Boddeke, H.W.G.M.

PY - 2015

Y1 - 2015

N2 - Microglia are a proliferative population of resident brain macrophages that under physiological conditions self-renew independent of hematopoiesis. Microglia are innate immune cells actively surveying the brain and are the earliest responders to injury. During aging, microglia elicit an enhanced innate immune response also referred to as 'priming'. To date, it remains unknown whether telomere shortening affects the proliferative capacity and induces priming of microglia. We addressed this issue using early (first-generation G1 mTerc

AB - Microglia are a proliferative population of resident brain macrophages that under physiological conditions self-renew independent of hematopoiesis. Microglia are innate immune cells actively surveying the brain and are the earliest responders to injury. During aging, microglia elicit an enhanced innate immune response also referred to as 'priming'. To date, it remains unknown whether telomere shortening affects the proliferative capacity and induces priming of microglia. We addressed this issue using early (first-generation G1 mTerc

U2 - https://doi.org/10.1111/acel.12370

DO - https://doi.org/10.1111/acel.12370

M3 - Article

SN - 1474-9718

VL - 14

SP - 1003

EP - 1013

JO - Aging cell

JF - Aging cell

IS - 6

ER -