Enhanced sensitivity of dopaminergic neurons to rotenone-induced toxicity with aging

Amie L Phinney; Gerda Andringa; John G J M Bol; Erik Ch Wolters; Freek L van Muiswinkel; Anne-Marie W van Dam; Benjamin Drukarch

doi:https://doi.org/10.1016/j.parkreldis.2005.12.002

Enhanced sensitivity of dopaminergic neurons to rotenone-induced toxicity with aging

Amie L Phinney, Gerda Andringa, John G J M Bol, Erik Ch Wolters, Freek L van Muiswinkel, Anne-Marie W van Dam, Benjamin Drukarch

Research output: Contribution to journal › Article › Academic › peer-review

45 Citations (Scopus)

Abstract

Rotenone has been reported to induce various degrees of Parkinsonism in rats. We tested whether advancing age alters the sensitivity of dopaminergic neurons to rotenone. A low, systemic dose of rotenone had no effect on young rats, but led to a 20-30% reduction of tyrosine hydroxylase-positive neurons in the substantia nigra of older rats. The effect was specific to nigral dopaminergic neurons and may be associated with the increase of glial cell activation in older rats. These data suggest that age enhances the sensitivity of dopaminergic neurons to rotenone and should be considered when assessing models of Parkinson's disease.

Original language	English
Pages (from-to)	228-38
Number of pages	11
Journal	Parkinsonism and Related Disorders
Volume	12
Issue number	4
DOIs	https://doi.org/10.1016/j.parkreldis.2005.12.002
Publication status	Published - May 2006

Keywords

Aging
Animals
Astrocytes
Cell Count
Dopamine
Immunohistochemistry
Insecticides
Journal Article
Male
Microglia
Neostriatum
Neurons
Neurotransmitter Agents
Presynaptic Terminals
Rats
Rats, Inbred Lew
Research Support, Non-U.S. Gov't
Rotenone
Substantia Nigra
Tyrosine 3-Monooxygenase
alpha-Synuclein

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https://doi.org/10.1016/j.parkreldis.2005.12.002

Cite this

@article{a2a806e908af4c55aae4b54e6f601c5c,

title = "Enhanced sensitivity of dopaminergic neurons to rotenone-induced toxicity with aging",

abstract = "Rotenone has been reported to induce various degrees of Parkinsonism in rats. We tested whether advancing age alters the sensitivity of dopaminergic neurons to rotenone. A low, systemic dose of rotenone had no effect on young rats, but led to a 20-30% reduction of tyrosine hydroxylase-positive neurons in the substantia nigra of older rats. The effect was specific to nigral dopaminergic neurons and may be associated with the increase of glial cell activation in older rats. These data suggest that age enhances the sensitivity of dopaminergic neurons to rotenone and should be considered when assessing models of Parkinson's disease.",

keywords = "Aging, Animals, Astrocytes, Cell Count, Dopamine, Immunohistochemistry, Insecticides, Journal Article, Male, Microglia, Neostriatum, Neurons, Neurotransmitter Agents, Presynaptic Terminals, Rats, Rats, Inbred Lew, Research Support, Non-U.S. Gov't, Rotenone, Substantia Nigra, Tyrosine 3-Monooxygenase, alpha-Synuclein",

author = "Phinney, {Amie L} and Gerda Andringa and Bol, {John G J M} and Wolters, {Erik Ch} and {van Muiswinkel}, {Freek L} and {van Dam}, {Anne-Marie W} and Benjamin Drukarch",

year = "2006",

month = may,

doi = "https://doi.org/10.1016/j.parkreldis.2005.12.002",

language = "English",

volume = "12",

pages = "228--38",

journal = "Parkinsonism and Related Disorders",

issn = "1353-8020",

publisher = "Elsevier BV",

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T1 - Enhanced sensitivity of dopaminergic neurons to rotenone-induced toxicity with aging

AU - Phinney, Amie L

AU - Andringa, Gerda

AU - Bol, John G J M

AU - Wolters, Erik Ch

AU - van Muiswinkel, Freek L

AU - van Dam, Anne-Marie W

AU - Drukarch, Benjamin

PY - 2006/5

Y1 - 2006/5

N2 - Rotenone has been reported to induce various degrees of Parkinsonism in rats. We tested whether advancing age alters the sensitivity of dopaminergic neurons to rotenone. A low, systemic dose of rotenone had no effect on young rats, but led to a 20-30% reduction of tyrosine hydroxylase-positive neurons in the substantia nigra of older rats. The effect was specific to nigral dopaminergic neurons and may be associated with the increase of glial cell activation in older rats. These data suggest that age enhances the sensitivity of dopaminergic neurons to rotenone and should be considered when assessing models of Parkinson's disease.

AB - Rotenone has been reported to induce various degrees of Parkinsonism in rats. We tested whether advancing age alters the sensitivity of dopaminergic neurons to rotenone. A low, systemic dose of rotenone had no effect on young rats, but led to a 20-30% reduction of tyrosine hydroxylase-positive neurons in the substantia nigra of older rats. The effect was specific to nigral dopaminergic neurons and may be associated with the increase of glial cell activation in older rats. These data suggest that age enhances the sensitivity of dopaminergic neurons to rotenone and should be considered when assessing models of Parkinson's disease.

KW - Aging

KW - Animals

KW - Astrocytes

KW - Cell Count

KW - Dopamine

KW - Immunohistochemistry

KW - Insecticides

KW - Journal Article

KW - Male

KW - Microglia

KW - Neostriatum

KW - Neurons

KW - Neurotransmitter Agents

KW - Presynaptic Terminals

KW - Rats

KW - Rats, Inbred Lew

KW - Research Support, Non-U.S. Gov't

KW - Rotenone

KW - Substantia Nigra

KW - Tyrosine 3-Monooxygenase

KW - alpha-Synuclein

U2 - https://doi.org/10.1016/j.parkreldis.2005.12.002

DO - https://doi.org/10.1016/j.parkreldis.2005.12.002

M3 - Article

C2 - 16488175

SN - 1353-8020

VL - 12

SP - 228

EP - 238

JO - Parkinsonism and Related Disorders

JF - Parkinsonism and Related Disorders

IS - 4

ER -