TY - JOUR
T1 - Epidemiological, Mycobacteriological, and Clinical Characteristics of Smoking Pulmonary Tuberculosis Patients, in Lambaréné, Gabon
T2 - A Cross-Sectional Study
AU - Adegbite, Bayode Romeo
AU - Edoa, Jean Ronald
AU - Achimi Agbo, Pacome
AU - Dejon-Agobé, Jean Claude
AU - N Essone, Paulin
AU - Lotola-Mougeni, Fabrice
AU - Mbong Ngwese, Mirabeau
AU - Mfoumbi, Arnault
AU - Mevyann, Chester
AU - Epola, Micheska
AU - Zinsou, Jeannot Frejus
AU - Honkpehedji, Yabo Josiane
AU - Agnandji, Selidji Todagbe
AU - Kremsner, Peter Gottfried
AU - Alabi, Abraham Sunday
AU - Adegnika, Ayola Akim
AU - Grobusch, Martin Peter
PY - 2020/12
Y1 - 2020/12
N2 - Gabon carries a high burden of both tuberculosis (TB) and smoking. This study examines the disease characteristics of smoking pulmonary TB patients in Lambaréné. We interviewed adult pulmonary TB patients in Lambaréné, between March 2016 and April 2019. Clinical and biological patient characteristics were collected. Bivariate and logistic regression analyses were performed to assess factors associated with smoking. The mean age of patients included was 31 years (±13). The proportion of smokers in our study was 30% (89/295). Smoking was significantly associated with patient-related diagnostic delay (adjusted odds ratio [AOR] = 8.18; 95% CI = 3.67-19.56), a higher number of pulmonary TB signs and symptoms (AOR = 2.74; 95% CI = 1.18-6.73), and a higher sputum mycobacterial load (AOR = 3.18; 95% CI = 1.33-8.11). The prevalence of smoking among TB patients is high, and leading to aggravated disease as compared with controls. Our study findings suggest that smoking patients should be regularly screened for TB, to reduce diagnostic delay and TB transmission within community. Smoking cessation activities should be included in the national TB control program in Gabon.
AB - Gabon carries a high burden of both tuberculosis (TB) and smoking. This study examines the disease characteristics of smoking pulmonary TB patients in Lambaréné. We interviewed adult pulmonary TB patients in Lambaréné, between March 2016 and April 2019. Clinical and biological patient characteristics were collected. Bivariate and logistic regression analyses were performed to assess factors associated with smoking. The mean age of patients included was 31 years (±13). The proportion of smokers in our study was 30% (89/295). Smoking was significantly associated with patient-related diagnostic delay (adjusted odds ratio [AOR] = 8.18; 95% CI = 3.67-19.56), a higher number of pulmonary TB signs and symptoms (AOR = 2.74; 95% CI = 1.18-6.73), and a higher sputum mycobacterial load (AOR = 3.18; 95% CI = 1.33-8.11). The prevalence of smoking among TB patients is high, and leading to aggravated disease as compared with controls. Our study findings suggest that smoking patients should be regularly screened for TB, to reduce diagnostic delay and TB transmission within community. Smoking cessation activities should be included in the national TB control program in Gabon.
KW - Adolescent
KW - Adult
KW - Antitubercular Agents/therapeutic use
KW - Cigarette Smoking/adverse effects
KW - Cross-Sectional Studies
KW - Female
KW - Gabon/epidemiology
KW - Humans
KW - Male
KW - Middle Aged
KW - Odds Ratio
KW - Risk Factors
KW - Tuberculosis, Pulmonary/complications
KW - Young Adult
UR - http://www.scopus.com/inward/record.url?scp=85097210671&partnerID=8YFLogxK
U2 - https://doi.org/10.4269/ajtmh.20-0424
DO - https://doi.org/10.4269/ajtmh.20-0424
M3 - Article
C2 - 32975178
SN - 0002-9637
VL - 103
SP - 2501
EP - 2505
JO - American journal of tropical medicine and hygiene
JF - American journal of tropical medicine and hygiene
IS - 6
ER -