Epidemiological, Mycobacteriological, and Clinical Characteristics of Smoking Pulmonary Tuberculosis Patients, in Lambaréné, Gabon: A Cross-Sectional Study

Bayode Romeo Adegbite, Jean Ronald Edoa, Pacome Achimi Agbo, Jean Claude Dejon-Agobé, Paulin N Essone, Fabrice Lotola-Mougeni, Mirabeau Mbong Ngwese, Arnault Mfoumbi, Chester Mevyann, Micheska Epola, Jeannot Frejus Zinsou, Yabo Josiane Honkpehedji, Selidji Todagbe Agnandji, Peter Gottfried Kremsner, Abraham Sunday Alabi, Ayola Akim Adegnika, Martin Peter Grobusch

Research output: Contribution to JournalArticleAcademicpeer-review

9 Citations (Scopus)

Abstract

Gabon carries a high burden of both tuberculosis (TB) and smoking. This study examines the disease characteristics of smoking pulmonary TB patients in Lambaréné. We interviewed adult pulmonary TB patients in Lambaréné, between March 2016 and April 2019. Clinical and biological patient characteristics were collected. Bivariate and logistic regression analyses were performed to assess factors associated with smoking. The mean age of patients included was 31 years (±13). The proportion of smokers in our study was 30% (89/295). Smoking was significantly associated with patient-related diagnostic delay (adjusted odds ratio [AOR] = 8.18; 95% CI = 3.67-19.56), a higher number of pulmonary TB signs and symptoms (AOR = 2.74; 95% CI = 1.18-6.73), and a higher sputum mycobacterial load (AOR = 3.18; 95% CI = 1.33-8.11). The prevalence of smoking among TB patients is high, and leading to aggravated disease as compared with controls. Our study findings suggest that smoking patients should be regularly screened for TB, to reduce diagnostic delay and TB transmission within community. Smoking cessation activities should be included in the national TB control program in Gabon.

Original languageEnglish
Pages (from-to)2501-2505
Number of pages5
JournalAmerican journal of tropical medicine and hygiene
Volume103
Issue number6
DOIs
Publication statusPublished - Dec 2020

Keywords

  • Adolescent
  • Adult
  • Antitubercular Agents/therapeutic use
  • Cigarette Smoking/adverse effects
  • Cross-Sectional Studies
  • Female
  • Gabon/epidemiology
  • Humans
  • Male
  • Middle Aged
  • Odds Ratio
  • Risk Factors
  • Tuberculosis, Pulmonary/complications
  • Young Adult

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