TY - JOUR
T1 - Epigenetic perturbations in aging stem cells
AU - Krauss, Sara Russo
AU - de Haan, Gerald
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Stem cells maintain homeostasis in all regenerating tissues during the lifespan of an organism. Thus, age-related functional decline of such tissues is likely to be at least partially explained by molecular events occurring in the stem cell compartment. Some of these events involve epigenetic changes, which may dictate how an aging genome can lead to differential gene expression programs. Recent technological advances have made it now possible to assess the genome-wide distribution of an ever-increasing number of epigenetic marks. As a result, the hypothesis that there may be a causal role for an altered epigenome contributing to the functional decline of cells, tissues, and organs in aging organisms can now be explored. In this paper, we review recent developments in the field of epigenetic regulation of stem cells, and how this may contribute to aging.
AB - Stem cells maintain homeostasis in all regenerating tissues during the lifespan of an organism. Thus, age-related functional decline of such tissues is likely to be at least partially explained by molecular events occurring in the stem cell compartment. Some of these events involve epigenetic changes, which may dictate how an aging genome can lead to differential gene expression programs. Recent technological advances have made it now possible to assess the genome-wide distribution of an ever-increasing number of epigenetic marks. As a result, the hypothesis that there may be a causal role for an altered epigenome contributing to the functional decline of cells, tissues, and organs in aging organisms can now be explored. In this paper, we review recent developments in the field of epigenetic regulation of stem cells, and how this may contribute to aging.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84969988190&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/27229519
U2 - https://doi.org/10.1007/s00335-016-9645-8
DO - https://doi.org/10.1007/s00335-016-9645-8
M3 - Review article
C2 - 27229519
SN - 0938-8990
VL - 27
SP - 396
EP - 406
JO - Mammalian Genome
JF - Mammalian Genome
IS - 7-8
ER -