Epigenetic regulation of macrophage function

Research output: PhD ThesisPhd-Thesis - Research and graduation internal

Abstract

Atherosclerosis is a lipid-driven chronic inflammatory disorder with a key role for macrophages in all disease stages. Macrophages are involved as scavengers of lipids, regulate inflammation, attract other immune cells and contribute to the resolution of inflammation, fibrosis and plaque stability. In this thesis, I investigate the potential for intervening at the level of transcriptional and epigenetic regulation to manipulate macrophages to dampen inflammation and to combat atherosclerosis. I conclude that macrophage function is tightly regulated by epigenetic processes and postulate that specific targeting of epigenetic enzymes or processes in innate immune cells, like macrophages, should be considered as future therapeutic opportunity in disease.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
Supervisors/Advisors
  • de Winther, Menno, Supervisor
  • Lutgens, E., Supervisor
Award date14 Oct 2016
Print ISBNs9789461699336
Publication statusPublished - 2016

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