TY - JOUR
T1 - Esophageal and gastric malignancies after bariatric surgery
T2 - a retrospective global study
AU - Parmar, Chetan
AU - Zakeri, Roxanna
AU - Abouelazayem, Mohamed
AU - Shin, Thomas H.
AU - Aminian, Ali
AU - Mahmoud, Tala
AU - Abu Dayyeh, Barham K.
AU - Wee, Melissa Y.
AU - Fischer, Laura
AU - Daams, Freek
AU - Mahawar, Kamal
AU - OGMOS Study Group
AU - Gallardo, Carlos Sosa
AU - Agustin, Cataldo
AU - Wright, Fernando
AU - Fuente, Ignacio
AU - Carbajo, Miguel
AU - Cal, Patricio
AU - Chisholm, Jacob
AU - Kow, Lilian
AU - Tan, Michael H. L.
AU - Gan, Philip
AU - Gananadha, Sivakumar
AU - Felsenreich, Daniel M.
AU - Prager, Gerhard
AU - Matthys, Chris
AU - Himpens, Jacques M.
AU - Focquet, Marc A. M. R. M.
AU - Ramos, Almino
AU - Nato, Manoel Galvano
AU - Vidal, Thiago
AU - Andalib, Amin
AU - Siblini, Aya
AU - Ferri, Lorenzo
AU - Abdarabo, Lina
AU - Nevo, Yehonatan
AU - Pescarus, Radu
AU - Yang, Wah
AU - Hamed, Hosam
AU - Liagre, Arnaud
AU - Bergeat, Damien
AU - Marie, De Montrichard
AU - Martini, Francesco
AU - Regis, François
AU - Genser, Laurent
AU - Skalli, Mehdi
AU - Nedelcu, Marius
AU - Smejkal, Milan
AU - Kassir, Radwan
AU - Kasteleijn, Anne
AU - Plat, Victor D.
N1 - Funding Information: A. Dayyeh has served as a speaker for Johnson and Johnson, Endogastric Solutions, and Olympus. He is a consultant to Medtronics. R. Zakeri is funded by a Royal College of Surgeons of England Research Fellowship. The other authors report no conflicts of interest. Publisher Copyright: © 2021 American Society for Bariatric Surgery
PY - 2022/4
Y1 - 2022/4
N2 - Background: Bariatric surgery can influence the presentation, diagnosis, and management of gastrointestinal cancers. Esophagogastric (EG) malignancies in patients who have had a prior bariatric procedure have not been fully characterized. Objective: To characterize EG malignancies after bariatric procedures. Setting: University Hospital, United Kingdom. Methods: We performed a retrospective, multicenter observational study of patients with EG malignancies after bariatric surgery to characterize this condition. Results: This study includes 170 patients from 75 centers in 25 countries who underwent bariatric procedures between 1985 and 2020. At the time of the bariatric procedure, the mean age was 50.2 ± 10 years, and the mean weight 128.8 ± 28.9 kg. Women composed 57.3% (n = 98) of the population. Most (n = 64) patients underwent a Roux-en-Y gastric bypass (RYGB) followed by adjustable gastric band (AGB; n = 46) and sleeve gastrectomy (SG; n = 43). Time to cancer diagnosis after bariatric surgery was 9.5 ± 7.4 years, and mean weight at diagnosis was 87.4 ± 21.9 kg. The time lag was 5.9 ± 4.1 years after SG compared to 9.4 ± 7.1 years after RYGB and 10.5 ± 5.7 years after AGB. One third of patients presented with metastatic disease. The majority of tumors were adenocarcinoma (82.9%). Approximately 1 in 5 patients underwent palliative treatment from the outset. Time from diagnosis to mortality was under 1 year for most patients who died over the intervening period. Conclusion: The Oesophago-Gastric Malignancies After Obesity/Bariatric Surgery study presents the largest series to date of patients developing EG malignancies after bariatric surgery and attempts to characterize this condition.
AB - Background: Bariatric surgery can influence the presentation, diagnosis, and management of gastrointestinal cancers. Esophagogastric (EG) malignancies in patients who have had a prior bariatric procedure have not been fully characterized. Objective: To characterize EG malignancies after bariatric procedures. Setting: University Hospital, United Kingdom. Methods: We performed a retrospective, multicenter observational study of patients with EG malignancies after bariatric surgery to characterize this condition. Results: This study includes 170 patients from 75 centers in 25 countries who underwent bariatric procedures between 1985 and 2020. At the time of the bariatric procedure, the mean age was 50.2 ± 10 years, and the mean weight 128.8 ± 28.9 kg. Women composed 57.3% (n = 98) of the population. Most (n = 64) patients underwent a Roux-en-Y gastric bypass (RYGB) followed by adjustable gastric band (AGB; n = 46) and sleeve gastrectomy (SG; n = 43). Time to cancer diagnosis after bariatric surgery was 9.5 ± 7.4 years, and mean weight at diagnosis was 87.4 ± 21.9 kg. The time lag was 5.9 ± 4.1 years after SG compared to 9.4 ± 7.1 years after RYGB and 10.5 ± 5.7 years after AGB. One third of patients presented with metastatic disease. The majority of tumors were adenocarcinoma (82.9%). Approximately 1 in 5 patients underwent palliative treatment from the outset. Time from diagnosis to mortality was under 1 year for most patients who died over the intervening period. Conclusion: The Oesophago-Gastric Malignancies After Obesity/Bariatric Surgery study presents the largest series to date of patients developing EG malignancies after bariatric surgery and attempts to characterize this condition.
KW - Bariatric surgery
KW - Esophageal cancer
KW - Esophagogastric cancer
KW - Gastric cancer
KW - Metabolic surgery
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85123075204&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/35065887
U2 - https://doi.org/10.1016/j.soard.2021.11.024
DO - https://doi.org/10.1016/j.soard.2021.11.024
M3 - Article
C2 - 35065887
SN - 1550-7289
VL - 18
SP - 464
EP - 472
JO - Surgery for Obesity and Related Diseases
JF - Surgery for Obesity and Related Diseases
IS - 4
ER -