Estimating the risk of squamous cell cancer induction in skin following nonlinear optical imaging

Giju Thomas; Oleg Nadiarnykh; Johan van Voskuilen; Christopher L. Hoy; Hans C. Gerritsen; Henricus J. C. M. Sterenborg

doi:https://doi.org/10.1002/jbio.201200207

Estimating the risk of squamous cell cancer induction in skin following nonlinear optical imaging

Giju Thomas, Oleg Nadiarnykh, Johan van Voskuilen, Christopher L. Hoy, Hans C. Gerritsen, Henricus J. C. M. Sterenborg

Biomedical Engineering and Physics (AMC)

Research output: Contribution to journal › Article › Academic › peer-review

7 Citations (Scopus)

Abstract

High power femto-second (fs) laser pulses used for in-vivo nonlinear optical (NLO) imaging can form cyclobutane pyrimidine dimers (CPD) in DNA, which may lead to carcinogenesis via subsequent mutations. Since UV radiation from routine sun exposure is the primary source of CPD lesions, we evaluated the risk of CPD-related squamous cell carcinoma (SCC) in human skin due to NLO imaging relative to that from sun exposure. We developed a unique cancer risk model expanding previously published estimation of risk from exposure to continuous wave (CW) laser. This new model showed that the increase in CPD-related SCC in skin from NLO imaging is negligible above that due to regular sun exposure

Original language	English
Pages (from-to)	492-505
Journal	Journal of Biophotonics
Volume	7
Issue number	7
DOIs	https://doi.org/10.1002/jbio.201200207
Publication status	Published - 2014

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https://doi.org/10.1002/jbio.201200207

Cite this

@article{bee42e646aa04620ab11762e7a287f78,

title = "Estimating the risk of squamous cell cancer induction in skin following nonlinear optical imaging",

abstract = "High power femto-second (fs) laser pulses used for in-vivo nonlinear optical (NLO) imaging can form cyclobutane pyrimidine dimers (CPD) in DNA, which may lead to carcinogenesis via subsequent mutations. Since UV radiation from routine sun exposure is the primary source of CPD lesions, we evaluated the risk of CPD-related squamous cell carcinoma (SCC) in human skin due to NLO imaging relative to that from sun exposure. We developed a unique cancer risk model expanding previously published estimation of risk from exposure to continuous wave (CW) laser. This new model showed that the increase in CPD-related SCC in skin from NLO imaging is negligible above that due to regular sun exposure",

author = "Giju Thomas and Oleg Nadiarnykh and {van Voskuilen}, Johan and Hoy, {Christopher L.} and Gerritsen, {Hans C.} and Sterenborg, {Henricus J. C. M.}",

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AU - Thomas, Giju

AU - Nadiarnykh, Oleg

AU - van Voskuilen, Johan

AU - Hoy, Christopher L.

AU - Gerritsen, Hans C.

AU - Sterenborg, Henricus J. C. M.

PY - 2014

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AB - High power femto-second (fs) laser pulses used for in-vivo nonlinear optical (NLO) imaging can form cyclobutane pyrimidine dimers (CPD) in DNA, which may lead to carcinogenesis via subsequent mutations. Since UV radiation from routine sun exposure is the primary source of CPD lesions, we evaluated the risk of CPD-related squamous cell carcinoma (SCC) in human skin due to NLO imaging relative to that from sun exposure. We developed a unique cancer risk model expanding previously published estimation of risk from exposure to continuous wave (CW) laser. This new model showed that the increase in CPD-related SCC in skin from NLO imaging is negligible above that due to regular sun exposure

U2 - https://doi.org/10.1002/jbio.201200207

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