European Prevention of Alzheimer's Dementia Registry: Recruitment and prescreening approach for a longitudinal cohort and prevention trials

Lisa Vermunt, Wiesje van der Flier, Giovanni B. Frisoni, Idris Guessous, Miia Kivipelto, Moira Marizzoni, Pablo Martinez-Lage, José Luis Molinuevo, David Porteous, Karen Ritchie, Philip Scheltens, Pierre Jean Ousset, Craig W. Ritchie, Gerald Luscan, Pieter Jelle Visser

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)

Abstract

Introduction: It is a challenge to find participants for Alzheimer's disease (AD) prevention trials within a short period of time. The European Prevention of Alzheimer's Dementia Registry (EPAD) aims to facilitate recruitment by preselecting subjects from ongoing cohort studies. This article introduces this novel approach. Methods: A virtual registry, with access to risk factors and biomarkers for AD through minimal data sets of ongoing cohort studies, was set up. Results: To date, ten cohorts have been included in the EPAD. Around 2500 participants have been selected, using variables associated with the risk for AD. Of these, 15% were already recruited in the EPAD longitudinal cohort study, which serves as a trial readiness cohort. Discussion: This study demonstrates that a virtual registry can be used for the preselection of participants for AD studies.

Original languageEnglish
Pages (from-to)837-842
Number of pages6
JournalAlzheimer's and Dementia
Volume14
Issue number6
DOIs
Publication statusPublished - 1 Jun 2018

Keywords

  • Clinical trial
  • EPAD
  • Participant recruitment
  • Preclinical AD
  • Prodromal AD
  • Research registry

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