Evaluating medical tests and biomarkers: In primary studies and systematic reviews

J. Wang

Research output: Doctoral thesisThesis, fully internal


This thesis addresses methodological problems in the evaluation of tests and biomarkers, in quite distinct types of research. The first part addresses systematic reviews and meta-analysis of diagnostic accuracy: discrimination between diseased and non-diseased (cross-sectional design; dichotomous test use). The second part presents primary studies of prognostic factors and clinical prediction rules: the probability of developing an event (continuous test result) in studies that include a time element. Both parts focus on discrimination between patient groups and the best ways to assess and express the discriminating ability of a test or model.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Bossuyt, P.M.M., Supervisor, External person
  • Zwinderman, A.H., Supervisor
  • Leeflang, Mariska M. G., Co-supervisor
  • Geskus, R.B.G., Co-supervisor
Award date13 Oct 2017
Print ISBNs9789462957442
Publication statusPublished - 2017

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