Evaluation of the role of the endocytic receptor L-SIGN for cytoadhesion of Plasmodium falciparum-infected erythrocytes

Nicola K Viebig, Katherine T Andrews, Yvette van Kooyk, Michael Lanzer, Percy A Knolle

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)


Hepatic cell populations play an important role during the malaria life cycle. L-SIGN, a homologue of DC-SIGN, mediating leukocyte and pathogen binding, is selectively expressed on liver endothelial cells. Here, we present evidence that L-SIGN acts as an endocytic cell surface receptor. However, P. falciparum-infected erythrocytes did not cytoadhere to L-SIGN. Thus, L-SIGN contributes to elimination of mannosylated ligands but does not participate in hepatic clearance of P. falciparum-infected erythrocytes.

Original languageEnglish
Pages (from-to)247-52
Number of pages6
JournalExperimental Parasitology
Issue number4
Publication statusPublished - Jun 2005


  • Animals
  • CHO Cells/metabolism
  • Cell Adhesion
  • Cell Adhesion Molecules/metabolism
  • Cricetinae
  • Cricetulus
  • Erythrocytes/metabolism
  • Humans
  • Lectins, C-Type/metabolism
  • Malaria, Falciparum/metabolism
  • Nerve Tissue Proteins/metabolism
  • Plasmodium falciparum/physiology
  • Receptors, Cell Surface/metabolism

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