Evaluation of the role of the endocytic receptor L-SIGN for cytoadhesion of Plasmodium falciparum-infected erythrocytes

Nicola K Viebig; Katherine T Andrews; Yvette van Kooyk; Michael Lanzer; Percy A Knolle

doi:https://doi.org/10.1007/s00436-005-1360-4

Evaluation of the role of the endocytic receptor L-SIGN for cytoadhesion of Plasmodium falciparum-infected erythrocytes

Nicola K Viebig, Katherine T Andrews, Yvette van Kooyk, Michael Lanzer, Percy A Knolle

Molecular cell biology and Immunology (VUmc)

Research output: Contribution to journal › Article › Academic › peer-review

2 Citations (Scopus)

Abstract

Hepatic cell populations play an important role during the malaria life cycle. L-SIGN, a homologue of DC-SIGN, mediating leukocyte and pathogen binding, is selectively expressed on liver endothelial cells. Here, we present evidence that L-SIGN acts as an endocytic cell surface receptor. However, P. falciparum-infected erythrocytes did not cytoadhere to L-SIGN. Thus, L-SIGN contributes to elimination of mannosylated ligands but does not participate in hepatic clearance of P. falciparum-infected erythrocytes.

Original language	English
Pages (from-to)	247-52
Number of pages	6
Journal	Experimental Parasitology
Volume	96
Issue number	4
DOIs	https://doi.org/10.1007/s00436-005-1360-4
Publication status	Published - Jun 2005

Keywords

Animals
CHO Cells/metabolism
Cell Adhesion
Cell Adhesion Molecules/metabolism
Cricetinae
Cricetulus
Erythrocytes/metabolism
Humans
Lectins, C-Type/metabolism
Malaria, Falciparum/metabolism
Nerve Tissue Proteins/metabolism
Plasmodium falciparum/physiology
Receptors, Cell Surface/metabolism

Access to Document

https://doi.org/10.1007/s00436-005-1360-4

Cite this

@article{17ce37a926004aa499ba2ab78de1d563,

title = "Evaluation of the role of the endocytic receptor L-SIGN for cytoadhesion of Plasmodium falciparum-infected erythrocytes",

abstract = "Hepatic cell populations play an important role during the malaria life cycle. L-SIGN, a homologue of DC-SIGN, mediating leukocyte and pathogen binding, is selectively expressed on liver endothelial cells. Here, we present evidence that L-SIGN acts as an endocytic cell surface receptor. However, P. falciparum-infected erythrocytes did not cytoadhere to L-SIGN. Thus, L-SIGN contributes to elimination of mannosylated ligands but does not participate in hepatic clearance of P. falciparum-infected erythrocytes.",

keywords = "Animals, CHO Cells/metabolism, Cell Adhesion, Cell Adhesion Molecules/metabolism, Cricetinae, Cricetulus, Erythrocytes/metabolism, Humans, Lectins, C-Type/metabolism, Malaria, Falciparum/metabolism, Nerve Tissue Proteins/metabolism, Plasmodium falciparum/physiology, Receptors, Cell Surface/metabolism",

author = "Viebig, {Nicola K} and Andrews, {Katherine T} and Kooyk, {Yvette van} and Michael Lanzer and Knolle, {Percy A}",

year = "2005",

month = jun,

doi = "https://doi.org/10.1007/s00436-005-1360-4",

language = "English",

volume = "96",

pages = "247--52",

journal = "Experimental parasitology",

issn = "0014-4894",

publisher = "Academic Press Inc.",

number = "4",

}

TY - JOUR

T1 - Evaluation of the role of the endocytic receptor L-SIGN for cytoadhesion of Plasmodium falciparum-infected erythrocytes

AU - Viebig, Nicola K

AU - Andrews, Katherine T

AU - Kooyk, Yvette van

AU - Lanzer, Michael

AU - Knolle, Percy A

PY - 2005/6

Y1 - 2005/6

N2 - Hepatic cell populations play an important role during the malaria life cycle. L-SIGN, a homologue of DC-SIGN, mediating leukocyte and pathogen binding, is selectively expressed on liver endothelial cells. Here, we present evidence that L-SIGN acts as an endocytic cell surface receptor. However, P. falciparum-infected erythrocytes did not cytoadhere to L-SIGN. Thus, L-SIGN contributes to elimination of mannosylated ligands but does not participate in hepatic clearance of P. falciparum-infected erythrocytes.

AB - Hepatic cell populations play an important role during the malaria life cycle. L-SIGN, a homologue of DC-SIGN, mediating leukocyte and pathogen binding, is selectively expressed on liver endothelial cells. Here, we present evidence that L-SIGN acts as an endocytic cell surface receptor. However, P. falciparum-infected erythrocytes did not cytoadhere to L-SIGN. Thus, L-SIGN contributes to elimination of mannosylated ligands but does not participate in hepatic clearance of P. falciparum-infected erythrocytes.

KW - Animals

KW - CHO Cells/metabolism

KW - Cell Adhesion

KW - Cell Adhesion Molecules/metabolism

KW - Cricetinae

KW - Cricetulus

KW - Erythrocytes/metabolism

KW - Humans

KW - Lectins, C-Type/metabolism

KW - Malaria, Falciparum/metabolism

KW - Nerve Tissue Proteins/metabolism

KW - Plasmodium falciparum/physiology

KW - Receptors, Cell Surface/metabolism

U2 - https://doi.org/10.1007/s00436-005-1360-4

DO - https://doi.org/10.1007/s00436-005-1360-4

M3 - Article

C2 - 15875214

SN - 0014-4894

VL - 96

SP - 247

EP - 252

JO - Experimental parasitology

JF - Experimental parasitology

IS - 4

ER -