TY - JOUR
T1 - Evolutionary shaping of human brain dynamics
AU - Pang, James C.
AU - Rilling, James K.
AU - Roberts, James A.
AU - van den Heuvel, Martijn P.
AU - Cocchi, Luca
N1 - Funding Information: We thank John Murray, Alex Fornito, and Luke Hearne for valuable scientific discussions. Human HCP data used for replication of results were provided by the Human Connectome Project, Wu-Minn Consortium (Principal Investigators: David Van Essen and Kamil Ugurbil; 1U54MH091657) funded by the 16 NIH Institutes and Centers that support the NIH Blueprint for Neuroscience Research, and by the McDonnell Center for Systems Neuroscience at Washington University. This work was supported by National Health and Medical Research Council grants 11144936 and 1145168 to J.A.R, Netherlands Organization for Scientific Research grants ALWOP.179, VIDI (452-16-015), and European Research Council Consolidator grant 101001062 to M.P.V.D.H., and National Health and Medical Research Council grants 1138711 and 2001283 to L.C. Funding Information: Funded by the 16 NIH Institutes and Centers that support the NIH Blueprint for Neuroscience Research, and by the McDonnell Center for Systems Neuroscience at Washington University. This work was supported by National Health and Medical Research Council grants 11144936, 1145168 to J.A.R, ALWOP.179, VIDI (452-16-015), 101001062 to M.P.V.D.H., 1138711 and 2001283 to L.C. . Publisher Copyright: © 2022, eLife Sciences Publications Ltd. All rights reserved.
PY - 2022
Y1 - 2022
N2 - The human brain is distinct from those of other species in terms of size, organization, and connectivity. How do structural evolutionary differences drive patterns of neural activity enabling brain function? Here, we combine brain imaging and biophysical modeling to show that the anatomical wiring of the human brain distinctly shapes neural dynamics. This shaping is characterized by a narrower distribution of dynamic ranges across brain regions compared with that of chimpanzees, our closest living primate relatives. We find that such a narrow dynamic range distribution supports faster integration between regions, particularly in transmodal systems. Conversely, a broad dynamic range distribution as seen in chimpanzees facilitates brain processes relying more on neural interactions within specialized local brain systems. These findings suggest that human brain dynamics have evolved to foster rapid associative processes in service of complex cognitive functions and behavior.
AB - The human brain is distinct from those of other species in terms of size, organization, and connectivity. How do structural evolutionary differences drive patterns of neural activity enabling brain function? Here, we combine brain imaging and biophysical modeling to show that the anatomical wiring of the human brain distinctly shapes neural dynamics. This shaping is characterized by a narrower distribution of dynamic ranges across brain regions compared with that of chimpanzees, our closest living primate relatives. We find that such a narrow dynamic range distribution supports faster integration between regions, particularly in transmodal systems. Conversely, a broad dynamic range distribution as seen in chimpanzees facilitates brain processes relying more on neural interactions within specialized local brain systems. These findings suggest that human brain dynamics have evolved to foster rapid associative processes in service of complex cognitive functions and behavior.
UR - http://www.scopus.com/inward/record.url?scp=85142002874&partnerID=8YFLogxK
U2 - https://doi.org/10.7554/eLife.80627
DO - https://doi.org/10.7554/eLife.80627
M3 - Article
C2 - 36286251
SN - 2050-084X
VL - 11
SP - 1
EP - 62
JO - eLife
JF - eLife
ER -