Abstract
In this high resolution magnetic resonance spectroscopic study of experimental allergic encephalomyelitis (EAE) and Semliki Forest virus (SFV) infection of the Biozzi AB/H mouse, marked increases in the initially low levels of N-trimethyl compounds in the spinal cord were observed during probable demyelinating episodes. There was also a pronounced and reproducible modulation of the levels of taurine and myo-inositol during acute and again during chronic relapsing EAE. The ratio of N-acetyl-aspartate to creatine in the spinal cord of mice infected with the mutant M9 strain of SFV decreased to approximately 70% of that seen in normal mice.
| Original language | English |
|---|---|
| Pages (from-to) | 692-7 |
| Number of pages | 6 |
| Journal | Magnetic resonance in medicine |
| Volume | 32 |
| Issue number | 6 |
| Publication status | Published - Dec 1994 |
Keywords
- Alphavirus Infections
- Animals
- Aspartic Acid
- Chromatography, High Pressure Liquid
- Comparative Study
- Creatine
- Encephalitis, Viral
- Encephalomyelitis, Autoimmune, Experimental
- Inositol
- Journal Article
- Magnetic Resonance Spectroscopy
- Mice
- Mice, Inbred Strains
- Research Support, Non-U.S. Gov't
- Semliki forest virus
- Spinal Cord
- Taurine