TY - JOUR
T1 - Exploring gastrointestinal variables affecting drug and formulation behavior: Methodologies, challenges and opportunities
AU - Hens, Bart
AU - Corsetti, Maura
AU - Spiller, Robin
AU - Marciani, Luca
AU - Vanuytsel, Tim
AU - Tack, Jan
AU - Talattof, Arjang
AU - Amidon, Gordon L.
AU - Koziolek, Mirko
AU - Weitschies, Werner
AU - Wilson, Clive G.
AU - Bennink, Roelof J.
AU - Brouwers, Joachim
AU - Augustijns, Patrick
PY - 2017
Y1 - 2017
N2 - Various gastrointestinal (GI) factors affect drug and formulation behavior after oral administration, including GI transfer, motility, pH and GI fluid volume and composition. An in-depth understanding of these physiological and anatomical variables is critical for a continued progress in oral drug development. In this review, different methodologies (invasive versus non-invasive) to explore the impact of physiological variables on formulation behavior in the human GI tract are presented, revealing their strengths and limitations. The techniques mentioned allow for an improved understanding of the role of following GI variables: gastric emptying (magnetic resonance imaging (MRI), scintigraphy, acetaminophen absorption technique, ultrasonography, breath test, intraluminal sampling and telemetry), motility (MRI, small intestinal/colonic manometry and telemetry), GI volume changes (MRI and ultrasonography), temperature (telemetry) and intraluminal pH (intraluminal sampling and telemetry)
AB - Various gastrointestinal (GI) factors affect drug and formulation behavior after oral administration, including GI transfer, motility, pH and GI fluid volume and composition. An in-depth understanding of these physiological and anatomical variables is critical for a continued progress in oral drug development. In this review, different methodologies (invasive versus non-invasive) to explore the impact of physiological variables on formulation behavior in the human GI tract are presented, revealing their strengths and limitations. The techniques mentioned allow for an improved understanding of the role of following GI variables: gastric emptying (magnetic resonance imaging (MRI), scintigraphy, acetaminophen absorption technique, ultrasonography, breath test, intraluminal sampling and telemetry), motility (MRI, small intestinal/colonic manometry and telemetry), GI volume changes (MRI and ultrasonography), temperature (telemetry) and intraluminal pH (intraluminal sampling and telemetry)
U2 - https://doi.org/10.1016/j.ijpharm.2016.11.063
DO - https://doi.org/10.1016/j.ijpharm.2016.11.063
M3 - Review article
C2 - 27915009
SN - 0378-5173
VL - 519
SP - 79
EP - 97
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
IS - 1-2
ER -