Expression of interleukin-10 activity by Epstein-Barr virus protein BCRF1

D. H. Hsu; R. de Waal Malefyt; D. F. Fiorentino; M. N. Dang; P. Vieira; J. de Vries; H. Spits; T. R. Mosmann; K. W. Moore

doi:https://doi.org/10.1126/science.2173142

Expression of interleukin-10 activity by Epstein-Barr virus protein BCRF1

D. H. Hsu, R. de Waal Malefyt, D. F. Fiorentino, M. N. Dang, P. Vieira, J. de Vries, H. Spits, T. R. Mosmann, K. W. Moore

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Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Cytokine synthesis inhibitory factor (CSIF; interleukin-10), a product of mouse TH2 T cell clones that inhibits synthesis of cytokines by mouse TH1 T cell clones, exhibits extensive sequence similarity to an uncharacterized open reading frame in the Epstein-Barr virus BCRF1. Recombinant BCRF1 protein mimics the activity of interleukin-10, suggesting that BCRF1 may have a role in the interaction of the virus with the host's immune system

Original language	English
Pages (from-to)	830-832
Journal	Science
Volume	250
Issue number	4982
DOIs	https://doi.org/10.1126/science.2173142
Publication status	Published - 1990

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https://doi.org/10.1126/science.2173142

Cite this

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title = "Expression of interleukin-10 activity by Epstein-Barr virus protein BCRF1",

abstract = "Cytokine synthesis inhibitory factor (CSIF; interleukin-10), a product of mouse TH2 T cell clones that inhibits synthesis of cytokines by mouse TH1 T cell clones, exhibits extensive sequence similarity to an uncharacterized open reading frame in the Epstein-Barr virus BCRF1. Recombinant BCRF1 protein mimics the activity of interleukin-10, suggesting that BCRF1 may have a role in the interaction of the virus with the host's immune system",

author = "Hsu, {D. H.} and {de Waal Malefyt}, R. and Fiorentino, {D. F.} and Dang, {M. N.} and P. Vieira and {de Vries}, J. and H. Spits and Mosmann, {T. R.} and Moore, {K. W.}",

year = "1990",

doi = "https://doi.org/10.1126/science.2173142",

language = "English",

volume = "250",

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publisher = "American Association for the Advancement of Science",

number = "4982",

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T1 - Expression of interleukin-10 activity by Epstein-Barr virus protein BCRF1

AU - Hsu, D. H.

AU - de Waal Malefyt, R.

AU - Fiorentino, D. F.

AU - Dang, M. N.

AU - Vieira, P.

AU - de Vries, J.

AU - Spits, H.

AU - Mosmann, T. R.

AU - Moore, K. W.

PY - 1990

Y1 - 1990

N2 - Cytokine synthesis inhibitory factor (CSIF; interleukin-10), a product of mouse TH2 T cell clones that inhibits synthesis of cytokines by mouse TH1 T cell clones, exhibits extensive sequence similarity to an uncharacterized open reading frame in the Epstein-Barr virus BCRF1. Recombinant BCRF1 protein mimics the activity of interleukin-10, suggesting that BCRF1 may have a role in the interaction of the virus with the host's immune system

AB - Cytokine synthesis inhibitory factor (CSIF; interleukin-10), a product of mouse TH2 T cell clones that inhibits synthesis of cytokines by mouse TH1 T cell clones, exhibits extensive sequence similarity to an uncharacterized open reading frame in the Epstein-Barr virus BCRF1. Recombinant BCRF1 protein mimics the activity of interleukin-10, suggesting that BCRF1 may have a role in the interaction of the virus with the host's immune system

U2 - https://doi.org/10.1126/science.2173142

DO - https://doi.org/10.1126/science.2173142

M3 - Article

C2 - 2173142

SN - 0036-8075

VL - 250

SP - 830

EP - 832

JO - Science

JF - Science

IS - 4982

ER -