TY - JOUR
T1 - Ezetimibe/simvastatin (INEGY) in the treatment of hyperlipidaemia
AU - Kastelein, J. J. P.
AU - Sankatsing, R. R.
PY - 2005
Y1 - 2005
N2 - Ezetimibe/simvastatin (INEGY), a dual inhibitor of both cholesterol production and absorption, is a new approach to the management of hyperlipidaemia. Recent studies have shown that it produces greater reductions in low-density lipoprotein (LDL) cholesterol than the single inhibition of statin therapy, enabling many more patients to achieve their LDL cholesterol treatment goals. With ezetimibe/simvastatin therapy, reductions of up to 61% from baseline have been seen in LDL cholesterol, with clear improvements in other associated lipid fractions. It has been well tolerated across all studies, with a safety profile similar to that of statin therapy. This article will review clinical experience to date with ezetimibe/simvastatin, commenting upon its place and potential value in the prevention of cardiovascular disease
AB - Ezetimibe/simvastatin (INEGY), a dual inhibitor of both cholesterol production and absorption, is a new approach to the management of hyperlipidaemia. Recent studies have shown that it produces greater reductions in low-density lipoprotein (LDL) cholesterol than the single inhibition of statin therapy, enabling many more patients to achieve their LDL cholesterol treatment goals. With ezetimibe/simvastatin therapy, reductions of up to 61% from baseline have been seen in LDL cholesterol, with clear improvements in other associated lipid fractions. It has been well tolerated across all studies, with a safety profile similar to that of statin therapy. This article will review clinical experience to date with ezetimibe/simvastatin, commenting upon its place and potential value in the prevention of cardiovascular disease
U2 - https://doi.org/10.1111/j.1368-5031.2005.00737.x
DO - https://doi.org/10.1111/j.1368-5031.2005.00737.x
M3 - Article
C2 - 16351680
SN - 1368-5031
VL - 59
SP - 1464
EP - 1471
JO - International journal of clinical practice
JF - International journal of clinical practice
IS - 12
ER -