Abstract
| Original language | English |
|---|---|
| Article number | 17 |
| Number of pages | 7 |
| Journal | NPJ microgravity |
| Volume | 9 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Dec 2023 |
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In: NPJ microgravity, Vol. 9, No. 1, 17, 12.2023.
Research output: Contribution to journal › Review article › Academic › peer-review
TY - JOUR
T1 - Pathophysiology, risk, diagnosis, and management of venous thrombosis in space
T2 - where are we now?
AU - Harris, Katie M.
AU - Arya, Roopen
AU - Elias, Antoine
AU - Weber, Tobias
AU - Green, David A.
AU - Greaves, Danielle K.
AU - Petersen, Lonnie G.
AU - Roberts, Lara
AU - Kamine, Tovy Haber
AU - Mazzolai, Lucia
AU - Bergauer, Andrej
AU - Kim, David S.
AU - Olde Engberink, Rik H.
AU - zu Eulenberg, Peter
AU - Grassi, Bruno
AU - Zuccarelli, Lucrezia
AU - Baldassarre, Giovanni
AU - Tabury, Kevin
AU - Baatout, Sarah
AU - Jordan, Jens
AU - Blaber, Andrew P.
AU - Choukér, Alexander
AU - Russomano, Thais
AU - Goswami, Nandu
N1 - Funding Information: The authors would like to acknowledge the members of the topical team who contributed to the ideas and recommendations provided in this manuscript: ESA VT Topical Team Members. A.B. A.P.B. Andrew Winnard. Angelique Van Ombergen. A.E. Bianca Brix. B.G. D.K.G. D.A.G. D.S.K. Gerhard Cvirn. Giovanni Baldasarre. Guy Meyer. Hanns-Christian Gunga. James Pavela. J.J. Jens Tank. Jutta Gärtner. K.M.H. Kristina Kofler. L.R. L.G.P. L.M. L.Z. Myles George Harris. Patrick De Boever. P.z.E. Rado Pišot. Robert Riddell. Roopen Arya. Sargsyan Ashot. Sergi Vaquer. Setfan Du Plessis. T.W. T.H.K. Ulrich Limper. We are thankful to the European Space Agency and NASA for financial support of this project. The European Space Agency provided funding to cover the open access cost of this publication. Publication costs were covered specifically from the ESA-sponsored Topical Team on “Pathophysiology, risk and clinical presentation of venous thromboembolism (VTE) and its evaluation of its prevention, diagnosis, mitigation and management strategies in spaceflight” (Grant number 4000131108/20/NL/PG/pt) and NASA Grant number 80NSSC19K0020, PI. The project was funded by the European Space Agency and KBR GmbH. The funder (KBR GmbH) provided support in the form of salaries for the authors T.W. and D.A.G. but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Funding Information: The authors would like to acknowledge the members of the topical team who contributed to the ideas and recommendations provided in this manuscript: ESA VT Topical Team Members. A.B. A.P.B. Andrew Winnard. Angelique Van Ombergen. A.E. Bianca Brix. B.G. D.K.G. D.A.G. D.S.K. Gerhard Cvirn. Giovanni Baldasarre. Guy Meyer. Hanns-Christian Gunga. James Pavela. J.J. Jens Tank. Jutta Gärtner. K.M.H. Kristina Kofler. L.R. L.G.P. L.M. L.Z. Myles George Harris. Patrick De Boever. P.z.E. Rado Pišot. Robert Riddell. Roopen Arya. Sargsyan Ashot. Sergi Vaquer. Setfan Du Plessis. T.W. T.H.K. Ulrich Limper. We are thankful to the European Space Agency and NASA for financial support of this project. The European Space Agency provided funding to cover the open access cost of this publication. Publication costs were covered specifically from the ESA-sponsored Topical Team on “Pathophysiology, risk and clinical presentation of venous thromboembolism (VTE) and its evaluation of its prevention, diagnosis, mitigation and management strategies in spaceflight” (Grant number 4000131108/20/NL/PG/pt) and NASA Grant number 80NSSC19K0020, PI. The project was funded by the European Space Agency and KBR GmbH. The funder (KBR GmbH) provided support in the form of salaries for the authors T.W. and D.A.G. but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2023, The Author(s).
PY - 2023/12
Y1 - 2023/12
N2 - The recent incidental discovery of an asymptomatic venous thrombosis (VT) in the internal jugular vein of an astronaut on the International Space Station prompted a necessary, immediate response from the space medicine community. The European Space Agency formed a topical team to review the pathophysiology, risk and clinical presentation of venous thrombosis and the evaluation of its prevention, diagnosis, mitigation, and management strategies in spaceflight. In this article, we discuss the findings of the ESA VT Topical Team over its 2-year term, report the key gaps as we see them in the above areas which are hindering understanding VT in space. We provide research recommendations in a stepwise manner that build upon existing resources, and highlight the initial steps required to enable further evaluation of this newly identified pertinent medical risk.
AB - The recent incidental discovery of an asymptomatic venous thrombosis (VT) in the internal jugular vein of an astronaut on the International Space Station prompted a necessary, immediate response from the space medicine community. The European Space Agency formed a topical team to review the pathophysiology, risk and clinical presentation of venous thrombosis and the evaluation of its prevention, diagnosis, mitigation, and management strategies in spaceflight. In this article, we discuss the findings of the ESA VT Topical Team over its 2-year term, report the key gaps as we see them in the above areas which are hindering understanding VT in space. We provide research recommendations in a stepwise manner that build upon existing resources, and highlight the initial steps required to enable further evaluation of this newly identified pertinent medical risk.
UR - http://www.scopus.com/inward/record.url?scp=85148463768&partnerID=8YFLogxK
U2 - https://doi.org/10.1038/s41526-023-00260-9
DO - https://doi.org/10.1038/s41526-023-00260-9
M3 - Review article
C2 - 36797288
SN - 2373-8065
VL - 9
JO - NPJ microgravity
JF - NPJ microgravity
IS - 1
M1 - 17
ER -