TY - JOUR
T1 - Immediate or delayed oncoplastic surgery after breast conserving surgery at the Netherlands Cancer Institute
T2 - a cohort study of 251 cases
AU - van Loevezijn, Ariane A.
AU - Geluk, Charissa S.
AU - van den Berg, Marieke J.
AU - van Werkhoven, Erik D.
AU - Vrancken Peeters, Marie-Jeanne T. F. D.
AU - van Duijnhoven, Frederieke H.
AU - Hoornweg, Marije J.
N1 - Funding Information: This work was not supported by research grants. Publisher Copyright: © 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2023/4
Y1 - 2023/4
N2 - Purpose: Oncoplastic surgery (OPS) after breast conserving surgery is preferably performed during the same operation. Offering delayed OPS instead of mastectomy to patients with a high risk of tumor-positive margins allows breast conservation with the option of margin re-excision during OPS, without having to dismantle the reconstruction. We aimed to evaluate surgical outcomes after immediate and delayed OPS. Methods: We included early-stage breast cancer patients who underwent OPS at the Netherlands Cancer Institute between 2016 and 2019. Patients were selected for delayed OPS after multidisciplinary consultation if the risk of tumor-positive margins with immediate OPS was considered significant (> 30%). Groups were compared on baseline characteristics and short-term surgical outcomes. Results: Of 242 patients with 251 OPS, 130 (52%) OPS had neoadjuvant chemotherapy. Immediate OPS was performed in 176 (70%) cases and delayed OPS in 76 (30%). Selection for delayed OPS was associated with tumor size (OR 1.03, 95% CI 1.01–1.04), ILC (OR 2.61, 95% CI 1.10–6.20), DCIS (OR 3.45, 95% CI 1.42–8.34) and bra size (OR 0.76, 95% CI 0.62–0.94). Delayed and immediate OPS differed in tissue weight (54 vs. 67 g, p = 0.034), tissue replacement (51% vs. 26%, p <.001) and tumor-positive margins (66% vs. 18%, p <.001). Re-excision was performed in 48 (63%) delayed OPS and in 11 (6%) immediate OPS. Groups did not differ in complications (21% vs. 18%, p = 0.333). Breast conservation after immediate and delayed OPS was 98% and 93%, respectively. Conclusion: Performing delayed OPS in selected cases facilitated simultaneous margin re-excision without increasing complications, and resulted in an excellent breast conservation rate.
AB - Purpose: Oncoplastic surgery (OPS) after breast conserving surgery is preferably performed during the same operation. Offering delayed OPS instead of mastectomy to patients with a high risk of tumor-positive margins allows breast conservation with the option of margin re-excision during OPS, without having to dismantle the reconstruction. We aimed to evaluate surgical outcomes after immediate and delayed OPS. Methods: We included early-stage breast cancer patients who underwent OPS at the Netherlands Cancer Institute between 2016 and 2019. Patients were selected for delayed OPS after multidisciplinary consultation if the risk of tumor-positive margins with immediate OPS was considered significant (> 30%). Groups were compared on baseline characteristics and short-term surgical outcomes. Results: Of 242 patients with 251 OPS, 130 (52%) OPS had neoadjuvant chemotherapy. Immediate OPS was performed in 176 (70%) cases and delayed OPS in 76 (30%). Selection for delayed OPS was associated with tumor size (OR 1.03, 95% CI 1.01–1.04), ILC (OR 2.61, 95% CI 1.10–6.20), DCIS (OR 3.45, 95% CI 1.42–8.34) and bra size (OR 0.76, 95% CI 0.62–0.94). Delayed and immediate OPS differed in tissue weight (54 vs. 67 g, p = 0.034), tissue replacement (51% vs. 26%, p <.001) and tumor-positive margins (66% vs. 18%, p <.001). Re-excision was performed in 48 (63%) delayed OPS and in 11 (6%) immediate OPS. Groups did not differ in complications (21% vs. 18%, p = 0.333). Breast conservation after immediate and delayed OPS was 98% and 93%, respectively. Conclusion: Performing delayed OPS in selected cases facilitated simultaneous margin re-excision without increasing complications, and resulted in an excellent breast conservation rate.
KW - Breast cancer
KW - Breast conserving surgery
KW - Breast reconstruction
KW - Oncoplastic surgery
UR - http://www.scopus.com/inward/record.url?scp=85146690102&partnerID=8YFLogxK
U2 - https://doi.org/10.1007/s10549-022-06841-8
DO - https://doi.org/10.1007/s10549-022-06841-8
M3 - Article
C2 - 36690822
SN - 0167-6806
VL - 198
SP - 295
EP - 307
JO - Breast cancer research and treatment
JF - Breast cancer research and treatment
IS - 2
ER -