TY - JOUR
T1 - Reduced Skin Microbiome Diversity in Infancy Is Associated with Increased Risk of Atopic Dermatitis in High-Risk Children
AU - Halling, Anne-Sofie
AU - Fritz, Blaine Gabriel
AU - Gerner, Trine
AU - Rinnov, Maria Rasmussen
AU - Bay, Lene
AU - Knudgaard, Mette Hjorslev
AU - Ravn, Nina Haarup
AU - Trautner, Simon
AU - Ruge, Iben Frier
AU - Olesen, Caroline
AU - Díiaz-Pinées Cort, Isabel
AU - Skov, Lone
AU - Sørensen, Nikolaj
AU - Møller Rønnstad, Amalie Thorsti
AU - Thomsen, Simon F.
AU - Egeberg, Alexander
AU - Jakasa, Ivone
AU - Kezic, Sanja
AU - Bjarnsholt, Thomas
AU - Thyssen, Jacob P.
N1 - Funding Information: The study received financial support from LEO Foundation, Lundbeck Foundation, Novo Nordisk Foundation, Aage Bangs fond, ‘Savværksejer Jeppe Juhl og hustru Ovita Juhls Mindelegat,’ and Herlev and Gentofte Hospital Research Foundation. Conceptualization: ASH, MRR, TG, LS, JPT; Data Curation: ASH; Formal Analysis: ASH, BGF, NS, IDPC; Funding Acquisition: ASH, MRR, TG, JPT; Investigation: MRR, TG, ASH, NHR, MHK, JPT; Methodology: ASH, JPT; Writing – Original Draft Preparation: ASH, JPT; Writing – Review and Editing: ASH, BGF, TG, MRR, LB, MHK, NHR, ST, IFR, CO, IDPC, LS, NS, ATMR, SFT, AE, IJ, SK, TB, JPT, The study was conducted independently of these supports, and the funders had no influence on the study design or data analysis. Funding Information: The study received financial support from LEO Foundation , Lundbeck Foundation, Novo Nordisk Foundation, Aage Bangs fond, ‘Savværksejer Jeppe Juhl og hustru Ovita Juhls Mindelegat,’ and Herlev and Gentofte Hospital Research Foundation. Publisher Copyright: © 2023 The Authors
PY - 2023/10
Y1 - 2023/10
N2 - It is currently unknown whether alterations in the skin microbiome exist before development of atopic dermatitis (AD). In this prospective Danish birth cohort of 300 children, we examined whether skin microbiome alterations during the first 2 months of life were associated with an increased risk of AD in the first 2 years and its severity after adjustment for environmental factors and selected skin chemokine and natural moisturizing factor levels. We found no overall association between the skin microbiome at birth and age 2 months and AD during the first 2 years of life. However, when restricting the analysis to children with at least one parent with atopy, a lower alpha diversity at age 2 months was associated with an increased risk of AD (adjusted hazard ratio = 1.7, 95% confidence interval = 1.1–2.6). We observed a stronger association in children where both parents had atopy (adjusted hazard ratio = 4.4, 95% confidence interval = 1.1–18.2). The putative pathogenic role of changes in the skin microbiome on AD risk remains uncertain but may play a role in those with an atopic predisposition.
AB - It is currently unknown whether alterations in the skin microbiome exist before development of atopic dermatitis (AD). In this prospective Danish birth cohort of 300 children, we examined whether skin microbiome alterations during the first 2 months of life were associated with an increased risk of AD in the first 2 years and its severity after adjustment for environmental factors and selected skin chemokine and natural moisturizing factor levels. We found no overall association between the skin microbiome at birth and age 2 months and AD during the first 2 years of life. However, when restricting the analysis to children with at least one parent with atopy, a lower alpha diversity at age 2 months was associated with an increased risk of AD (adjusted hazard ratio = 1.7, 95% confidence interval = 1.1–2.6). We observed a stronger association in children where both parents had atopy (adjusted hazard ratio = 4.4, 95% confidence interval = 1.1–18.2). The putative pathogenic role of changes in the skin microbiome on AD risk remains uncertain but may play a role in those with an atopic predisposition.
UR - http://www.scopus.com/inward/record.url?scp=85162890838&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.jid.2023.03.1682
DO - https://doi.org/10.1016/j.jid.2023.03.1682
M3 - Article
C2 - 37085040
SN - 0022-202X
VL - 143
SP - 2030-2038.e6
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 10
ER -