TY - JOUR
T1 - Factors Associated With Functional Decline in Hand and Hip/Knee Osteoarthritis After One Year: Data From a Population-Based Study
AU - Siviero, Paola
AU - Limongi, Federica
AU - Gesmundo, Antonella
AU - Zambon, Sabina
AU - Cooper, Cyrus
AU - Dennison, Elaine M.
AU - Edwards, Mark H.
AU - van der Pas, Suzan
AU - Timmermans, Erik J.
AU - van Schoor, Natasja M.
AU - Schaap, Laura A.
AU - Dallmeier, Dhayana
AU - Denkinger, Michael D.
AU - Peter, Richard
AU - Castell, Maria Victoria
AU - Otero, Ángel
AU - Pedersen, Nancy L.
AU - Deeg, Dorly J. H.
AU - Maggi, Stefania
AU - European Project on Osteoarthritis Research Group
AU - Nikolaus, T.
AU - Peter, R.
AU - Denkinger, M. D.
AU - Herbolsheimer, F.
AU - Maggi, S.
AU - Zambon, S.
AU - Limongi, F.
AU - Noale, M.
AU - Siviero, P.
AU - Deeg, D. J.
AU - van der Pas, S.
AU - Schaap, L. A.
AU - van Schoor, N. M.
AU - Timmermans, E. J.
AU - Otero, A.
AU - Castell, M. V.
AU - Sanchez-Martinez, M.
AU - Quieipo, R.
AU - Pedersen, N. L.
AU - Broumandi, R.
AU - Dennison, E. M.
AU - Cooper, C.
AU - Edwards, M. H.
AU - Parsons, C.
N1 - Funding Information: The authors thank Linda Inverso Moretti for assistance in editing the manuscript. Publisher Copyright: © 2020, American College of Rheumatology
PY - 2021/9
Y1 - 2021/9
N2 - Objective: To investigate factors that together with hand or hip/knee osteoarthritis (OA) could contribute to functional decline over a year’s time in elderly individuals. Methods: The data of 1,886 individuals between ages 65 and 85 years in a prospective, observational population-based study with 12–18 months of follow-up in the context of the European Project on Osteoarthritis were analyzed. The outcome measures were self-reported hand and hip/knee functional decline, evaluated using a minimum clinically important difference of 4 on the Australian/Canadian Hand OA Index and of 2 on the Western Ontario and McMaster Universities Osteoarthritis Index hip/knee physical function subscales, both normalized to 0–100. Using regression models adjusted for sex, age, country, and education level, the baseline factors considered were clinical hand or hip/knee OA, pain, analgesic/antiinflammatory medications, comorbidities, social isolation, income, walking time, grip strength, physical activity time, and medical/social care. Results: After a year, 453 participants were identified as having worse hand functionality and 1,389 as not worse. Hand OA, anxiety, walking time, and grip strength were risk factors for hand functional decline; pain was a confounder of the effect of hand OA. Analgesic/antiinflammatory medications mediated the combined effect of hip/knee OA plus pain on functional decline in the 554 individuals classified as having worse hip/knee functionality and the 1,291 persons who were not worse. Peripheral artery disease, obesity, and cognitive impairment were other baseline risk factors. Conclusion: Study findings showed that together with emotional status and chronic physical and cognitive conditions, OA affects hand and hip/knee functional decline.
AB - Objective: To investigate factors that together with hand or hip/knee osteoarthritis (OA) could contribute to functional decline over a year’s time in elderly individuals. Methods: The data of 1,886 individuals between ages 65 and 85 years in a prospective, observational population-based study with 12–18 months of follow-up in the context of the European Project on Osteoarthritis were analyzed. The outcome measures were self-reported hand and hip/knee functional decline, evaluated using a minimum clinically important difference of 4 on the Australian/Canadian Hand OA Index and of 2 on the Western Ontario and McMaster Universities Osteoarthritis Index hip/knee physical function subscales, both normalized to 0–100. Using regression models adjusted for sex, age, country, and education level, the baseline factors considered were clinical hand or hip/knee OA, pain, analgesic/antiinflammatory medications, comorbidities, social isolation, income, walking time, grip strength, physical activity time, and medical/social care. Results: After a year, 453 participants were identified as having worse hand functionality and 1,389 as not worse. Hand OA, anxiety, walking time, and grip strength were risk factors for hand functional decline; pain was a confounder of the effect of hand OA. Analgesic/antiinflammatory medications mediated the combined effect of hip/knee OA plus pain on functional decline in the 554 individuals classified as having worse hip/knee functionality and the 1,291 persons who were not worse. Peripheral artery disease, obesity, and cognitive impairment were other baseline risk factors. Conclusion: Study findings showed that together with emotional status and chronic physical and cognitive conditions, OA affects hand and hip/knee functional decline.
UR - http://www.scopus.com/inward/record.url?scp=85108605441&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/acr.24404
DO - https://doi.org/10.1002/acr.24404
M3 - Article
C2 - 32770733
SN - 2151-464X
VL - 73
SP - 1343
EP - 1353
JO - Arthritis care and research
JF - Arthritis care and research
IS - 9
ER -