@article{488482b2781e4b59bd1bba3edda96ffc,
title = "Falciparum malaria mortality in sub-Saharan Africa in the pretreatment era",
abstract = "Driven by the malaria-protective effect of sickle-cell trait, balancing selection results in hemoglobin S equilibrium allele frequencies of between 15% and 20% in areas of high Plasmodium falciparum transmission in sub-Saharan Africa. From this we estimate that the malaria-attributable childhood mortality in the pretreatment era was between 15% and 24%.",
keywords = "falciparum malaria, hemoglobin S, malaria-attributable mortality, sickle cell",
author = "Watson, {James A.} and White, {Nicholas J.} and Dondorp, {Arjen M.}",
note = "Funding Information: The authors are funded by the Wellcome Trust ( 220211 ). For the purpose of Open Access, the author have applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission. J.W. is funded by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (grant number 223253/Z/21/Z ). Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",
year = "2022",
month = jan,
doi = "https://doi.org/10.1016/j.pt.2021.10.005",
language = "English",
volume = "38",
pages = "11--14",
journal = "Trends in parasitology",
issn = "1471-4922",
publisher = "Elsevier",
number = "1",
}